实验性血管钙化大鼠血浆抗氧化能力的变化观察.docVIP

精品论文 参考文献 实验性血管钙化大鼠血浆抗氧化能力的变化观察 韦肖敏 　　（广西医科大学第一附属医院血管外科 广西 南宁 530021） 　　【摘要】 目的：探讨实验性血管钙化大鼠血浆抗氧化能力的变化。方法：回顾性总结40只实验动物大鼠的相关实验资料及生化检验结果，对收集的数据进行统计学分析。结果：钙化组大鼠主动脉钙的含量均值为（1.55plusmn;0.24）mmol/g，碱性磷酸酶含量均值为（55.60plusmn;9.33）U/g，均明显高于对照组，在组织学考察结果方面，对照组大鼠超氧化物歧化酶和总抗氧化能力的值分别为（240.5plusmn;11.38）U/ml和（13.05plusmn;6.11）U/g，均明显高于钙化组，而丙二醛的平均值明显低于对照组[（2.77plusmn;0.35）nmol/mlVS（21.33plusmn;7.12）nmol/ml]（Plt;0.05）。结论：组织内氧化与抗氧化功能的失调可能会促使血管钙化的形成，如果能够增强机体的抗氧化能力可能会显著性改善血管的钙化现象。 　　【关键词】血管钙化；血浆；抗氧化能力；碱性磷酸酶 　　【中图分类号】R965 【文献标识码】A 【文章编号】2095-1752（2015）06-0037-02 　　Experimental vascular calcification in the rat plasma antioxidant capacity changes observed 　　Wei Xiaomin. The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China 　　【Abstract】Objective Discusses experimental vascular calcification in the rat plasma antioxidant capacity changes. Methods Retrospective summary only 40 rats of experimental animals related experimental data and biochemical test results, to collect data for statistical analysis. Results Rat aortic calcification group calcium as the tendency for g (1.55plusmn;0.24 mm), alkaline phosphatase levels averages (55.60 plusmn; 9.33) U/g, were significantly higher than that of control group, in terms of the histologic findings, the control group rats of superoxide dismutase (sod) and total antioxidant capacity value respectively (240.5plusmn;11.38) U/ml (13.05plusmn;6.11) U/g, and were significantly higher than that of calcium group, and the average of the malondialdehyde significantly lower than the control group (2.77plusmn;0.35) nmol/mlVS nmol/ml (21.33 plusmn; 7.12)] (P lt; 0.05). Conclusions Tissue oxidation and anti-oxidation function disorder may prompt the formation of vascular calcification, if can enhance the antioxidant capacity of the body could significantly improve vascular calcification. 　　【Key words】Vascular calcification;Plasma; Antioxidant capacity; Alkaline phosphatase 　　血管钙化是导致心血管事件的重要危险因素