奇正青鹏膏剂外用治疗类风湿关节炎止痛消肿作用的临床对照试验.docVIP

奇正青鹏膏剂外用治疗类风湿关节炎止痛消肿作用的临床对照试验 中国骨伤2009年12月第22卷第12期ChinaJOnhopamp;Trauma,Dec.2009,Vo1.22.No.12? 917? 临床研究? 奇正青鹏膏剂外用治疗类风湿关节炎止痛消肿 作用的临床对照试验 周彩云,潘峥,马芳,唐今杨 (中国中医科学院西苑医院风湿免疫科,北京100091) 【摘要】目的:评价奇正青鹏膏剂外用对类风湿关节炎关节疼痛肿胀的临床疗效.方法:自2004年12月至 2006年5月采用随机,平行对照临床研究方案,运用区组随机化方法,利用SAS软件的PROCPLAN语句,将78例患 者随机分为治疗组和对照组.治疗组40例,男30例,女10例,平均年龄(48.2±9.7)岁,用奇正青鹏膏剂外用治疗;对 照组38例,男30例,女8例,平均年龄(47.7±l3.7)岁,用双氯芬酸二乙胺乳胶剂外用.以掌指关节中肿痛最重的一个 关节作为观察关节,观察关节疼痛,关节压痛,关节肿胀,关节屈伸不利,晨僵等情况,根据尼莫地平法计算症状积分指 数WAS记分),进行疗效判定.结果:共有68例完成试验,治疗组35例,对照组33例.治疗2周末治疗组显效1例, 有效27例,无效7例;对照组显效2例,有效20例,无效11例,两组疗效差异无统计学意义.但治疗1周末治疗组关 节肿胀的评分为(4.0±1.4)分,低于对照组的(5.5±1.9)分.结论:奇正青鹏膏荆治疗类风湿性关节炎与双氯芬酸二乙胺 乳胶剂缓解关节疼痛疗效相当,奇正青鹏膏剂消肿作用更强. 【关键词】关节炎,类风湿;外治法;中药疗法;临床对照试验 ControlledclinicaltrialsofexternalusingofCheezhengQingpengointment(奇正青鹏膏)onrelivinganalgesiaand swellingforthetreatmentofrheumatoidarthritisZHOUCai梱un,PANZheng,MAFang,TANGn梱ang.TheXiyuan HospitalofChinaAcademyofChineseMedicalSciences,Beijing100091,China ABSTRACTObjective:ToobservetheclinicalefficacyonanalgesiaanddetumescenceofCheezhengQingpengointment (奇正青鹏膏)inthetreatmentofrheumatoidarthritis.Methods:FromDecember2004toMay2006,78patientsweredivided intothetreatmentgroupandthecontrolgrouprandomlyusingPROCPLANfromSASsoftware.Therewere40patientsinthe treatmentgroup.30patientsweremaleand10patientswerefemale,withanaverageageof(48.2-+9.7)years,whoweretreated withCheezhengQingpengointment(奇正青鹏膏)externaltreatment.Thirty—eightpatientswereinthecontrolgroup,30pa— tientsweremaleand8patientswerefemale,withanaverageageof(47.7-+13.7)years,andweretreatedwithDiclofenacdi?ethylamineemuge1.Al1thepatientsweretreatedfor2weeks.Themetacarpophalangealjointwithmostseverepainandswelling wasobserved.Theindexesincludingjointpain,tenderness,swelling,jointmotionandmorningstiffnessweredetectedandthe VASscoreswerecomparedbetweenthetwogroups.Results:Allthepatientscompletedthetrial,35patientsinthetreatment groupand33patientsinthecontrolgroup.Attheendof2weeks,lpatientinthetreatmentgroupobtainedanexcellentresult, 27gooda