微生物精品教学（汕头大学）Virology2012.pptVIP

* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * Interferon (IFN) 干扰素是由病毒或其他干扰素诱生剂刺激机体多种细胞所产生的一种具有抗病毒、抗肿瘤和免疫调节等多种生物学活性的糖蛋白 ?inhibit replication of a variety of viruses ?only inhibit replication of virus ?species-specific i.e. broad spectrum(广谱)/non-specific (not kill directly virus) Action of IFN in antitumor and immunoregalation Cytokines are the body’s first-line defense against viral infection prevention and cure immunoprophylaxis artificial active immunity Inactivated Vaccine vaccine prevention and cure immunoprophylaxis artificial active immunity Attenuated Vaccine vaccine prevention and cure immunoprophylaxis artificial active immunity Vector Vaccine Subunit Vaccine vaccine prevention and cure immunoprophylaxis artificial passive immunity Immunoglobulin Antibody Cytokines medicine 核苷类药物Nucleoside analogue 阿昔洛韦、阿糖腺苷、齐多夫定、肌酐、拉米夫定、利巴韦林 非核苷类逆转录酶抑制剂 RTase Inhibitor Viral proteinase inhibitor Chinese herbal medicine Interferon and IFN-inducer asON siRNA Ribozyme * Summary General features / structure of virus Main steps of viral replication Variation types Types of viral infection Virion, abortive infection, defective virus, interference, IFN, Cytocidal effect, CPE, inclusion body * * * * * * * * * * * * * * * * * * * * * * * * Growth curve of virus * Abnormal replication Abortive infection 顿挫感染 The viral infection of a cell in which viral components may be synthesized without the production of infective viruses. Also known as nonproductive infection. The cell, which induce viral abortive infection, also be called “Non-permissive cell” (非容纳细胞) Defective virus 缺陷病毒 A virus particle that contains insufficient nucleic acid to provide for production of all essential viral components, thus infection is not produced except under certain conditions, such as co-infection with “helper virus” (辅助病毒). * Interference interference inter