急性颅脑外伤患者治疗前后血浆ET-1和血清hs-CRP,cGRP.docVIP

精品论文 参考文献 急性颅脑外伤患者治疗前后血浆ET-1和血清hs-CRP,cGRP 张琳1 张世媚2 　　(1江苏省东海县洪庄镇中心卫生院 222336；2东海县人民医院 222300) 　　【摘要】目的：探讨急性卢脑外伤治疗前后血浆ET-1和血清cGRP水平的变化及临床意义。方法：应用放射免疫分析法和免疫比浊法对33例急性颅脑外伤患者进行了治疗前后血浆ET-1和hs-CRP,cGRP水平检测，并与35名正常健康人作比较。结果：在治疗前血浆ET-1和血清hs-CRP、cGRP水平均显著的高于正常人组（plt;0.01），经治疗二周后与正常人比较则无显著性差异（pgt;0.05），且血浆ET-1水平与hs-CRP,cGRP水平呈显著正相关（r=0.5982,0.6019,plt;0.01）。结论：检测血浆ET-1和血清hs-CRP、cGRP水平的变化对疾病的诊断治疗和预后判断均具有一定的临床价值。 　　【关键词】急性颅脑损伤 内皮素-1 超敏c-反应蛋白 降钙素基因相关肽 　　【中图分类号】R651 【文献标识码】A 【文章编号】2095-1752（2014）01-0074-02 　　Clinical significance of Measurement of changes of plasma ET-1 and Serum hs-CRP,cGRP levels after treatment in patients with Acute traumatic brain injury . 　　Jiangsu Donghai County Hongzhuang hospital zhang-lin Donghai County peoplersquo;s hospital zhang-shi-mei 　　【Abstract】Objective: To explore the significance of plasma ET-1 and serum hs-CRP CGRP levels after treatment in patients with Acute traumatic brain injury ,Metheds：the plasma ET-1 and serum CGRP(with RIA),Serum hs-CRP (with immune turbility method ) levels were determined in 33 patients with acute traumatic brain injury and 35 controls.Results：Before treatment ,plasma ET-1 and serum hs-CRP .cGRP levels were sigiticantly higher than those in controls (plt;0.01),after treatment for 2 weeks plasma ET-1 and serum hs-CRP cGRP levels were not significantly different from those in controls(pgt;0.05) plasma ET-1 levels were positive correlated with serum hs-CRP ,cGRP levels (r=0.5982,0.6019,plt;0.01) Conclusions ：changes of plasma ET-1 and serum hs-CRP cGRP levels might be of prognostic importance in patients with Acute traumatic brain injury. 　　【Key words】Acute traumatic brain injury Endothelin-1 CE Higher-sensitive c-reactive protein (hs-CRP) Calationin geneverelated peptide 　　文献证实[1]：ET-1为血管内皮细胞分泌的缩血管多肽，是迄今为止发现的血管收缩功能最强的内源性物质。hs-CRP为急性时相蛋白，对炎症、创伤均具有十分重要的临床价值[2]。cGRP为目前已知最强的舒血管物质之一[3]。本文报告急性颅脑外伤患者治疗前后血浆ET-1和血清hs-CRP、cGRP水平的变化。现将结果报告如下： 　　1.资料与方法 　　1