原创力文档皮肤癌相关文献复习及纳米雄黄干预P53、Bcl-2在A431细胞中表达的研究Literature review of skin cancer related literature and the intervention of nano realgar in the expression of P53 and Bcl-2 in A431 cells.pdfVIP
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皮肤癌相关文献复习及纳米雄黄干预P53、Bcl-2在A431细胞中表达的研究Literature review of skin cancer related literature and the intervention of nano realgar in the expression of P53 and Bcl-2 in A431 cells
摘 要
目的：考察纳米雄黄对皮肤鳞癌 A431 细胞凋亡的作用，探讨纳米雄黄诱导肿瘤
细胞凋亡和抑制增殖的机理。方法：本实验主要包括纳米雄黄通过机械研制法制备，
A431 细胞的形态学观察，运用免疫组化法、RT-PCR 技术探讨纳米雄黄诱导人皮肤鳞
癌 A431 细胞凋亡和抑制增殖的作用机理。结果：纳米雄黄可以明显诱导人皮肤鳞癌
A431 细胞的凋亡，且与顺铂联合应用有协同作用，并发现纳米雄黄诱导肿瘤人皮肤
鳞癌 A431 细胞凋亡的机理与上调 P53 的表达和下调Bcl-2 的表达有关。结论:纳米雄
黄可有效诱导皮肤鳞癌 A431 细胞发生凋亡。纳米雄黄可以通过诱导肿瘤细胞凋亡等
途径实现抗肿瘤作用，与顺铂联合用药，可产生协同作用。
关键词 纳米雄黄；细胞凋亡；人皮肤鳞癌 A431 细胞；Bcl-2 ；P53
Skin cancer -related literature review and the study on the
intervention of the expression of p53 Bcl-2 in A431 by Nanometer
Realgar
Speciality: Clinical internal Medicine of TCM
Author: Yan qin
Tutor: Professor Qi Yuanfu
Abstract
Objective: The study observes “Nanometer Realgar” curative effect to patients of
squamous cell carcinoma (SCC) and the mechanism of inducing the apoptosis of human
skin squamous cell carcinoma A431. Methods: in this experimental, mainly used
immunohistochemical and RT-PCR to observe the mechanism of inducing the apopotosis
of “Nanometer Realgar”to human skin squamous cell carcinoma cell line A431. Results:
Nanometer Realgar can significantly induce the apoptosis of human skin squamous cell
carcinoma cell line A431 by raising the level of P53 and reducing the level of Bcl- 2.
Conclusion: Nanometer Realgar can induce tumor cell apoptosis ways to antitumor
function, and combination therapy with DDP can produce synergy.
Key words “Nanometer Realgar”; inducing apoptosis of tumor cell; Human skin
squamous cell carcinoma cell line A431; Bcl-2; P53
目 录
引 言 1
第一部分 皮肤癌的理论探讨与文献复习 2
一、中医对
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