金钗石斛的化学成分和药理作用研究现状.docVIP

金钗石斛的化学成分和药理作用研究现状 周威 夏杰 孙文博 梁妍 郝小燕 汤磊 贵州医科大学药学院 贵州省化学合成药物研发利用工程技术研究中心 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 摘????要： 金钗石斛为常见传统中药, 药用历史悠久。目前, 国内外研究学者对金钗石斛进行了广泛深入的研究。通过系统查阅国内外期刊、数据库, 总结归纳了金钗石斛已报道的化学成分和药理作用。其化学成分按照其结构类型可分为:生物碱类、糖苷类、菲类和联苄类等, 金钗石斛的化学成分种类繁多, 其中石斛碱是其特征性成分;金钗石斛药理作用主要表现在抗肿瘤、降血糖以及对神经系统保护作用等方面。本文对迄今为止金钗石斛的化学成分和药理作用进行全面综述, 为该药材的药物开发、临床应用提供科学依据。 关键词： 金钗石斛; 化学成分; 药理作用; 研究进展; 作者简介：周威, 男, 药学博士, 硕士生导师, 副教授, 主要从事药物分析与新药开发。联系电话: (0851) E-mail:drwzhou@126.com。 作者简介：汤磊, 男, 博士生导师, 教授, 主要从事化学药物研究与开发。联系电话: (0851) E-mail:tlei1974@。 收稿日期：2017-09-01 基金：贵州省国际科技合作计划项目[黔科合外G字 (2014) 7010] Current research status of chemical constituents and pharmacological effects of Dendrobium nobile ZHOU Wei XIA Jie SUN Wen-bo LIANG Yan HAO Xiao-yan TANG Lei School of Pharmacy, Guizhou Medical University; Abstract： Dendrobium nobile as a common traditional Chinese medicine has a long history of medicinal application. At present, domestic and international scholars have conducted extensive and thorough research on Dendrobium nobile. Through systematic searching of domestic and foreign journals and databases, the chemical constituents and pharmacological effects of Dendrobium nobile were summarized. According to structural types, its chemical constituents can be classified as alkaloids, glycosides, phenanthrenes and bibenzils etc. There are many kinds of chemical constituents in Dendrobium nobile, among which dendrobine is the characteristic one. The pharmacological effects of Dendrobium nobile are mainly manifested as anticancer, hypoglycemic and neurological protective actions and so on. The purpose of this article is to provide scientific basis for development and clinical application of Dendrobium nobile. Keyword： Dendrobium nobile; chemical constituents; pharmacological effects; research progress; Received： 2017-09-01 金钗石斛 (Dendrobium nobile) 又名金钗石、扁黄草等, 为兰科石斛属植物, 主要药用部位为新鲜或干燥茎, 味甘、微咸、无毒, 主要分布于贵州、云南、广西等长江以南的亚热带地区[1]。金钗石斛在《中