稳定期慢性阻塞性肺疾病合并抑郁焦虑综合性干预的临床探讨.pdfVIP

第41卷第4期 广 州 医学 院学 报 Vol.41No.4 2013年8月 ACADEMICJOURNAL OF GUANGZHOU MEDICAL COLLEGE Aug.2013 ·临床实践 · 稳定期慢性阻塞性肺疾病合并抑郁焦虑综合性干预 的临床探讨 庄蝶微 (北京市第六医院呼吸内科,100007) 摇 摇 摘要摇 目的:探讨对稳定期慢性阻塞性肺疾病(COPD)合并抑郁焦虑的患者进行抗抑郁焦虑综合性 干预的作用。 方法:随机将68例COPD合并抑郁焦虑患者分为两组,对照组仅予常规治疗,治疗组在常 规治疗基础上加以帕罗西汀口服及综合性干预,并随访1年,收集两组患者1年前后抑郁焦虑评分;两组 患者1年前后肺功能、ACT评分、6 min步行距离并得出各自差值;收集两组当年急性发作次数,进行各自 统计学分析。 结果:治疗组1年后抑郁焦虑评分明显减低(P0.001),对照组无改善(P 0.05);治疗组 肺功能、ACT评分、6 min步行距离1年前后差值较对照组有显著差异(P0.05),当年急性发作次数治疗 组较对照组明显减少(P0.05)。 结论:对COPD稳定期合并抑郁焦虑进行综合性干预可改善患者的肺 功能,提高运动耐力,减少急性加重次数,从而减少患者的住院率及医疗负担。 关键词摇 慢性阻塞性肺疾病;抑郁焦虑;综合性干预 中图分类号:R563.5摇 文献标识码:A摇 文章编号:1008鄄1836(2013)04鄄0101鄄03 Effects of integratedintervention on depression andanxiety in clinically stable chronic obstructive pulmonary disease ZHUANGDie鄄wei (Department of Respiratory Medicine,Beijing No.6 Hospital,Beijing 100007,China) Abstract摇 Objective:To investigate the effects of integrated intervention on depression and anxiety in patients with clinically stable chronic obstructive pulmonary disease (COPD). Methods: Sixty鄄eight COPD patientswith depression and anxiety were randomly assigned to receive usual treatment (control group) or in combinationwith paroxetine and integrated intervention (treatment group). This entailed assessment of anxiety and depression,lung function,ACT score,6鄄minute鄄walk test and the number acute exacerbations prior to and following a 1鄄year therapy. Results:Treatment group,but not control group, had a marked improvement in depression and anxiety score (both P 0.05). Treatment group yielded a statistically significant difference in pulmonary function, ACT score and 6鄄minute鄄walk test and the number of acute exacerbations within the treatment period (all P 0.05) . Conclusion:Integrated intervention on depression and anxie