毛细胞型星形细胞瘤的临床病理特征的临床研究.docVIP

精品论文 参考文献 毛细胞型星形细胞瘤的临床病理特征的临床研究 吕晶1 王成鑫2 陈琼霞2 刘丽江2通讯作者 　　1.长江航运总医院武汉脑科医院病理科 湖北武汉 430000； 　　2.江大病理诊断所组织病理诊断室 湖北武汉 430053 　　【摘 要】目的：探讨毛细胞型星形细胞瘤的临床病理特征。方法：回顾性分析2例毛细胞型星形细胞瘤患者的临床资料。结果：本组2例均为男性，年龄分别为1岁及2岁。发病部位位于右侧小脑和后颅窝。本组例1镜下具有双相性的特点,由比例不等的致密区(含Rosenthal纤维)和疏松区(嗜酸性颗粒小体)相互交替组成, 肿瘤细胞呈梭形,有毛发样的突起的特点。例2镜下于大量粘液背景中见双极性的梭形细胞，未见Rosenthal纤维，其内血管增生。免疫标记显示，2例瘤细胞均阳性表达胶质纤维酸性蛋白（GFAP）、Vimentin蛋白（Vimentin）及S-100蛋白（S-100），而神经元特异性烯醇化酶（NSE）只在例1的瘤细胞中表达，2例Ki-67阳性率均lt;1%。结论：毛细胞型星形细胞瘤病理上分为毛细胞型星形细胞瘤和毛细胞粘液样型星形细胞瘤，均好发于儿童和青少年。毛细胞型星形细胞瘤的组织学特征是双相型，含有Rosenthal纤维和嗜酸性小体成分。毛细胞粘液样型星形细胞瘤是由双极性的梭形细胞组成,间质内含有大量的黏液。 　　【关键词】毛细胞型星形细胞瘤；临床病理；毛细胞粘液样型星形细胞瘤 　　【中图分类号】R739.4 【文献标识码】B 【文章编号】1674-8999（2015）8-0274-03 　　 Clinicopathological featuers of pilocytic astrocytoma (report of 2 cases ) 　　LV Jing1，WANG Cheng-Xing2, CHEN Qiong-Xia2，LIU Li-Jiang2 　　(1．General Hospital of the Yangtze River Shipping Wuhan Brain Hospital,Wuhan 430000,China; 　　2．Pathological diagnosis of Jianghan University, Wuhan 430053,China;） 　　【Abstract】Objective：To explore the Clinicopathological featuers of pilocytic astrocytomas. Methods：The clinical data of two pilocytic astrocytomas patients were analyzed retrospectively. Results：All the 2 cases occurred in male patients at the age of 1 years and 2 years respectively. Example one was located in the third cerebellar, while example two was located at the posterior fossa. Histologically, in the one case,the tumor was composed of biphasic pattern cells. Pilocytic astrocytoma characteristically contained alternative densely packed areas (contain rosenthal fibers) and loosely packed area(contain eosinophilic body). The tumor cells have fusiform shape and hair-like projections. Histologically, see a lot of mucus in the background of bipolar spindle cells, no rosenthal fiber. There are inner vascular proliferation. In the tow cases, immunohistochemical showed glial fibrillary acidic protein（GFAP），Vimentin protein（Vimentin）and S-100 protein（S-100）in neoplastic cell were positivity. But neu