缬沙坦联合氨氯地平治疗老年原发性高血压伴糖尿病的疗效.docVIP

精品论文 参考文献 缬沙坦联合氨氯地平治疗老年原发性高血压伴糖尿病的疗效 张秀玲 孙光春 杜茜 　　（复旦大学附属上海市第五人民医院 上海 200240） 　　【摘要】目的：探讨缬沙坦联合氨氯地平治疗老年原发性高血压伴糖尿病的疗效。方法：收集2013年4月～2015年1月我院诊断为原发性高血压伴糖尿病的老年患者，高血压分级I级、Ⅱ级。随机分为研究组（缬沙坦联合氨氯地平）和对照组（接受缬沙坦治疗）。对比两组治疗前后血压、空腹血糖、空腹胰岛素水平。结果：两组治疗前血压、空腹血糖、空腹胰岛素差异无统计学意义（Pgt;0.05），两组治疗后血压、空腹血糖、空腹胰岛素水平差异有统计学意义（Plt;0.05）。结论：缬沙坦联合氨氯地平治疗老年原发性高血压伴糖尿病，能明显改善患者血压水平，对降低胰岛素抵抗有重要的作用。 　　【关键词】缬沙坦；氨氯地平；原发性高血压；糖尿病 　　【中图分类号】R541.1 【文献标识码】A 【文章编号】1007-8231（2015）24-0018-02 　　Efficacy of valsartan combined with amlodipine in the treatment of elderly patients with essential hypertension and diabetes mellitus 　　【Abstract】 Objective To investigate the efficacy of valsartan combined with amlodipine in the treatment of elderly patients with essential hypertension and diabetes mellitus. Methods the elderly patients with essential hypertension and diabetes were collected from January ~2015, April 2013, and the grade I and II level of hypertension were collected. Randomly divided into study group (valsartan combined with amlodipine) and control group (treated with valsartan). Blood pressure, fasting blood glucose, fasting insulin levels were compared between the two groups before and after treatment. Results The treatment in the two groups before blood pressure, fasting blood glucose, fasting insulin were no statistical significance (P gt; 0.05), the two groups after treatment, blood pressure, fasting blood glucose, fasting insulin levels were with statistical significance (P lt; 0.05). Conclusion Valsartan combined with amlodipine in the treatment of elderly patients with primary hypertension and diabetes, can significantly improve the blood pressure level, to reduce the insulin resistance has an important role. 　　【Key words】Stan; amlodipine; Essential hypertension; Diabetes mellitus 　　老年人基础疾病多，容易伴发2种或多种心脑血管疾病，有学者指出在老年人原发性高血压人群中有20%～35%的患者同时伴有糖尿病。糖尿病和高血压共同发展，造成众多靶器官损伤。有研究[1]显示缬沙坦与氨氯地平单药能够改善糖尿病患者的胰岛素抵抗现象，而且对控制血压水平有较好的作用。因此本次研究拟收集我院2013年4月～2015年1月诊断为原发性高血压伴糖尿病的老年患者，探