血液灌流改善代谢综合征的临床研究.docVIP

精品论文 参考文献 血液灌流改善代谢综合征的临床研究 （徐州医学院第二附属医院血液透析中心 江苏 徐州 221000） 　　【摘要】 目的：观察血液灌注改善代谢综合征患者血脂紊乱，高血压，高血糖以及清除细胞因子的变化。方法：选取39例代谢综合征患者，采用树脂血液灌流器，以股静脉建立血管通路在费森尤斯4008S血液透析机上给与血液灌流120min，采集血液灌流前后血样，测定血脂，血糖，胰岛素，iPTH，肾素，血管紧张素II，ET，hsCRP的变化。结果：1.本研究共完成38例，男29例，女9例。血液灌流后患者SBP，DBP，TG，VLDL，TC，肾功，血常规，iPTH，血管紧张素II，ET，IL-6,TNFalpha;,胰岛素明显下降，差异有统计学意义（Plt;0.01）。LDL，HDL，肾素，血糖，hsCRP无明显变化（Pgt;0.05）2.血液灌流后患者白细胞计数升高18.74%，PLT，AST，ALT，Cr分别下降16.84%，6.52%，5.3%，差异有统计学意义。3.性别，年龄，BMI对血液灌流的血脂清除效率无明显影响。4.不良反应一共4例，均较轻微。2例轻微寒颤经保温后症状消失继续灌流，1例灌流结束后穿刺口出血，经加压包扎后未再出血，1例腹痛，查体未发现阳性体征，终止灌流后腹痛缓解，考虑精神紧张造成。由于该患者终止血液灌流，最终完成病例38例。结论：血液灌流可以安全有效地改善代谢综合征患者的血压，血脂紊乱，高胰岛素血症，并能够清除体内过多的炎症因子。 　　【关键词】 血液灌流；代谢综合征；脂代谢紊乱；高血压；高胰岛素血症 　　【中图分类号】R544.1 【文献标识码】A 【文章编号】2095-1752（2016）33-0022-02 　　Clinical study of blood perfusion improve the metabolic syndrome 　　Zhang Yanqiu, Zhang Dongmei, Nie Xiuling. Second Affiliated Hospital of Xuzhou Medical College, Jiangsu Province, Xuzhou 221000, China 　　【Abstract】 Objective To observe the blood perfusion improve blood lipid disorders in patients with metabolic syndrome, high blood pressure, high blood sugar changes. Methods Selection of 39 patients with the metabolic syndrome, collecting blood samples before and after the blood perfusion, determination of blood lipids, blood glucose, insulin, iPTH, renin, angiotensin II, ET, hsCRP changes. Results Blood perfusion after patients with SBP, DBP, TG, VLDL, TC, renal function, blood routine, iPTH, angiotensin II, ET, IL - 6, TNF alpha, insulin decreased obviously, elevated WBC count was 18.74%, PLT, AST, ALT, Cr decreased respectively 16.84%, 6.52%, 5.3%, the difference was statistically significant. Conclusions Blood perfusion can be safely and effectively improve the metabolic syndrome in patients with blood pressure, blood lipid disorders, high insulin hematic disease, and can remove excessive inflammation in the body. 　　【Key words】The blood perfusion; The metabolic syndrome; Lipid metabolism disorder;