阻塞性睡眠呼吸暂停低通气综合征18例临床分析.docVIP

精品论文 参考文献 阻塞性睡眠呼吸暂停低通气综合征18例临床分析 （贵阳市南明区人民医院老干综合科 贵州 贵阳 550002） 【摘 要】目的：通过检测阻塞性睡眠呼吸暂停低通气综合征(osAHs)患者血清血管内皮生长因子(VEGF)质量浓度，探讨其与肺动脉高压的关系。方法：选择2010年4月-2014年8月我院收治的18例因打鼾就诊的患者，次日晨7：00测定其血清VEGF质量浓度，并予超声心动图检测0SAHs患者肺动脉压力。结果：PsG检测结果显示与单纯鼾症组比，0sAHs组存在夜间低氧；且重度组比轻中度0SAHS组夜间低氧更严重(均有统计学意义)。与单纯鼾症组比较，VEGF质量浓度在重度0sAHs组中明显升高(Plt;0．05)，并分别与衡量病情及夜间低氧情况指标呈正相关，与夜间最低经皮血氧饱和度(SpO：)呈负相关。结论：中重度0SAHS患者存在夜间低氧饱和度，同时有VEGF增高。 【关键词】睡眠呼吸暂停综合征；血管内皮生长因子；肺动脉高压 【中图分类号】R766 【文献标识码】B 【文章编号】1003-5028（2015）6-0639-01 【Abstract】Objective：through the detection of obstructive sleep apnea hypopnea syndrom (osAHs) patients with serum vascular endothelial growth factor (VEGF) mass concentration, explore its relationship with pulmonary hypertension. Methods：in April 2010 - August 2014 18 cases of our hospital for patients with snoring visits, the next morning at 7:00 measure its quality of serum VEGF concentration, pulmonary artery pressure and echocardiography to detect 0 sahs patients. Results：PsG results show than to the simple sleep apnea group, 0 sahs group of low oxygen at night; And severe hypoxia group than in mild-to-moderate 0 sahs night more serious (have statistical significance). Compared with pure sleep apnea group, VEGF concentration in severe 0 sahs group increased significantly (P lt; 0.05), and respectively with measure and night low oxygen index were positively correlated, and at night the lowest percutaneous oxygen saturation (SpO) showed a negative correlation. Conclusions：relation between 0 sahs patients exist low oxygen saturation at night, at the same time have increased VEGF. 【Key words】sleep apnea syndrome; Vascular endothelial growth factor; Pulmonary arterial hypertension 阻塞性睡眠呼吸暂停低通气综合征(0sAHs)是一种发生率极高的疾病，具有一定潜在的危险性。OsAHs患者由于有夜间频繁的呼吸暂停、低通气发生，存在不同程度的夜间低氧血症，甚至有白天低氧的发生。血管内皮生长因子(VEGF)属生长因子中血小板衍化生长因子家族，它能特异性地作用于血管内皮细胞，具有促进内皮细胞增殖分化、新生血管形成及增加微血管通透性等功能，而低氧是VEGF表达的强烈诱导因素。目前OSAHs和心血管疾病密切关系日益受到人们的关注，0sAHs和VEGF及0sAHs和肺动脉高压的关系已有了一些报道，但有关VEGF与0sAHs患者肺动脉高压的关系国内外均未见报道。我们对两者的关