阿仑膦酸钠治疗继发性骨质疏松症的临床研究.docVIP

精品论文 参考文献 阿仑膦酸钠治疗继发性骨质疏松症的临床研究 王雄 (成都大学附属医院疼痛科 四川成都 610081) 【摘要】目的 观察阿仑膦酸钠治疗继发性骨质疏松症的疗效和安全性。方法 116例继发性骨质疏松症患者，选用阿仑膦酸钠治疗6个月。比较治疗前后患者疼痛、骨密度、血生化指标和副反应的变化。结果 经6个月治疗后，患者疼痛明显改善，腰椎、股骨颈和髋部骨密度增加，血清25-(OH)VD(25-羟维生素D)水平升高, BAP(骨型碱性磷酸酶)水平下降，PTH(甲状旁腺素)变化不明显，副反应轻微且耐受性好。结论 阿仑膦酸钠治疗继发骨质疏松症疗效显著、安全性好。 【关键词】阿仑膦酸钠 继发骨质疏松症 骨密度 副反应 【中图分类号】R969 【文献标识码】A 【文章编号】2095-1752（2014）19-0136-02 The Effect of Alendronate on diabetes patients complicated with osteoporosis .wang xiong. Department of Pain Medicine, Affiliated Hospital of Chengdu University, Chengdu, China. 610081 【Abstract】Objective To explore the effect and safety of Alendronate on patients complicated with secondary osteoporosis. Methods 116 patients complicated with secondary osteoporosis were treated with Alendronate, and the degree of pain, change of bone mineral density (BMD), bone metabolic biochemical markers and side effects were compared with treatment before. Results At 6 month after treatment, pain of the patients was relieved and the BMD of lumbar, femoral neck and hip were increased obviously. The serum 25-(OH)VD level was elevated and bone specific alkaline phosphatase decreased, parathyroid hormone did t changed significantly. The side effects weret tolerated slighly. Conclusion Alendronate is effective and safe for patients complicated with secondary osteoporosis. 【Key words】Alendronate patients complicated with secondary osteoporosis bone mineral density side effects 阿仑膦酸钠(Alendronate,ALN)作为一种高效的骨吸收抑制剂，临床上已用于防治原发性骨质疏松症[1，2]。国内研究多基于女性绝经后骨质疏松症患者，对继发性骨质疏松症的疗效报道较少。本文报道了阿仑膦酸钠治疗116例继发性骨质疏松症患者的疗效和安全性。 1 材料和方法 1.1 临床资料：选择成都大学附属医院内疼痛科2009年-2013年门诊继发性骨质疏松症患者58例，年龄57～79(平均64.15)岁。入选标准：腰椎或股骨上段任一处骨密度低于男性峰值骨量2.5SD者。其中有腰椎压缩性骨折病史16例，10例有股骨颈骨折病史，4例有前臂骨折病史，86例无骨折病史。 1.2 治疗方法：骨密度测定后1周内开始服用阿仑膦酸钠片(福善美，Merck Sharp amp; Dohme (Italy) S.P.A.) 每周1次，1次1片70mg每周固定的一天晨起时用一满杯白水送服，并且在服药后至少30分钟之内和当天第一次进食前，病人避