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IMAGE GUIDEDTHERAPIESMedia BriefingJune 19, 2003 S p o n s o r e d b y t h e Radiological Societyof North America Brain Aneurysms Successfully Treated Without Open Surgery V A S C U L A R D I S E A S E Jacques E. Dion, M.D. Emory University Hospital S p o n s o r e d b y t h e Radiological Society of North America Brain Aneurysms Successfully Treated Without Open Surgery Jacques E. Dion, M.D., FRCP (C) Professor of Radiology Neurosurgery Director, Interventional Neuroradiology Emory University Hospital Atlanta, GA History of Coiling 1987-1989: Dr Guido Guglielmi (University of Rome) visits Dr Vi?uela (Interventional Neuroradiologist) at UCLA and research work on coiling concept starts 1989: Dr Guglielmi comes permanently to UCLA 1989-1990: Bench and animal research March 6, 1990: First clinical use of Guglielmi Detachable Coil FDA approval in 1995 International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomized trial The Lancet Vol 360, October 26, 2002 Aneurysm Demographics Aneurysms are found in 2-5% of the population There are as many as 27,000 aneurysms that could be diagnosed and treated per year in the U.S. They are more common in women (Sharon Stone had an aneurysm that was treated with coils by an interventional neuroradiologist) The annual rupture rate is approximately 1.5% Rupture of an aneurysm results in approximately 50% mortality and 25% stroke incidence Aneurysm Facts Factors believed to contribute to brain aneurysms: Smoking Hypertension Traumatic head injury Alcohol use Use of oral contraception Family history of brain aneurysms Other inherited disorders: Ehler’s syndrome, polycystic kidney disease, and Marfan syndrome Aneurysm Facts Symptoms of ruptured aneurysms: The worst headache of your life Localized and intense headache Nausea and vomiting Stiff neck or neck pain Blurred or double vision Pain above and