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Neonatal Cold Injury Syndrome
(sclerema neonatorum);
Objectives;Distribution of neonatal brown fat; Cold injury
● Cold environment increase heat loss, low body
temperature causes constriction of peripheral
blood vessels, dysfunction of microcirculation
● Low body temperature and cold environment
cause anoxia, metabolic disturbance and
acidosis even multiple organ dysfunction (MOD);
;Imbalance between heat production and loss;Imbalance between heat production and loss;immature of temperature center
relative larger surface ;Anoxia, acidosis; multiple organ dysfunction
● bradycardia, dyspnea,
● microcirculation disturbance,
● shock, DIC,
● acute renal failure,
● pulmonary hemorrhage;Evaluation of body surface area; Degrees of NCIS
Body temperature(℃) involved area change of organic
anus T axil – anus T (%、color) function
I0 ≥ 35 positive 20 no change
(mild) pale
II0 35 0 or positive 20~50 poor reaction
(moderate) dark red bradycardia
III0 35 negative 50 shock、DIC、
(severe) or 30 cyanotic PH or ARF; nonspecific examination for diagnosis.
blood gas analysis, CT, PT,
blood glucose level, platelet,
electrolytes, BUN,
fibrogen, etc.
EKG, X - ray
;Differential diagnosis;Neonatal edema ;Differential diagnosis;Neonatal Subcutaneous Gangrene;treatment;Treatment
● Restoration of body temperature
● Energy supply and fluid infusion
● Correction of organ dysfunction
· correction of acidosis and volume expansion
· treatment of pulmonary hemorrhag
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