More About Clustering - Penn State Department of Statistics 更多关于聚类-宾夕法尼亚州立大学统计系.ppt

下载文档 降价啦

8
0
约1.18万字
约 36页
2018-04-17 发布于江西
举报
版权申诉
保障服务

More About Clustering - Penn State Department of Statistics 更多关于聚类-宾夕法尼亚州立大学统计系.ppt

1、本文档共36页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。

More About Clustering Naomi Altman Nov 06 Assessing Clusters Some things we might like to do: Understand the within cluster similarity and between cluster differences in terms of distances and expression profiles. Decide how many clusters are in the data. Display the clusters graphically. Determine cluster stability. Determine stability of genes in a cluster. Assessing Clusters Understand the within cluster similarity and between cluster differences in terms of distances and expression profiles. Decide how many clusters are in the data. Distance similarity: genes in the same cluster should be closer together than genes in different clusters. Expression similarity: genes in the same cluster should have expression profiles that are more similar (on features of interest) than genes in different clusters. (And if this is not true, maybe we need a different similarity measure.) Display the clusters graphically. Determine cluster stability. Determine stability of genes in a cluster. Distance similarity: Genes in the same cluster should be closer together than genes in different clusters. Some criteria Using Height In hierarchical clustering, we can use the cluster height to help determine where to define clusters. complete.out=hclust(dist(M.yeast),method=complete) plot(1:293,complete.out$height,ylab=Distance at Join,main=Complete Linkage) Using Heightin Hierarchical Clustering Assessing Clusters Understand the within cluster similarity and between cluster differences in terms of distances and expression profiles. Decide how many clusters are in the data. Display the clusters graphically. How do the clusters relate to the treatments? What are the typical expression profiles for genes in the clusters Determine cluster stability. Determine stability of genes in a cluster. Plotting Cluster Centers # All of the clustering routines provide a vector in the same order # as the genes, with the cluster number. # For hierarchical methods, you need to cut the