线粒体活性氧与糖尿病性白内障的关系及茶多酚干预作用的实验研究-中西医结合临床专业论文.docx

优秀毕业论文 精品参考文献资料 m m ito e h o n d ria in c re a se d sig n if ie a n tly . W lle re a s，th e e e lls e u iru re d in h ig h c o n c e n tra tio n 9 lu e o se in te rf ere d w ith T P m a in ta in e d g o o d m o r p h a a 一ld v ia b ility . T lle M M P . R O S a n d e lld o e y to P la sm ie re tie u lu m in c e lls tu rlle d b a e k to b a la n e e a s e u ltu re d in n o rm a l m e d iu m . T h e re su lts in m e d ia w ith d if fe re n t T P e o n e e n tra tio n s w e re a lm o st th e sa m e . v itro rest in d ie a te in 8 w e e k s th e m o d e ls e sta b lish e d ，7 6 .2 % o f d iab e tie rat le n se s in S T Z 一D M g ro u P sh o w e d lll e la ss o P a c ity ，A n d th at th e re w e re o n ly 3 0 % o f d ia b etie rat Ie n s sh o w e d 11 e la ss o P a e ity in T P 一D M g ro u P ，T h is o P a e ity d e v e lo P e d in e v id e n tly .In 1 2 w e e k s ， le n s o f S T Z 一D M g ro u P w e re to ta l o P a e ity ，a n d o n ly 6 1 .1% o f th e le n s in T P 一D M g ro u P sh o w e d Ille la ss o P a e ity . W h en th e u ltra m ic ro stru etu re o f rat le n s w a s o b serv e d w ith S E M ，w e f o u n d th a t th e e ry sta llin e f ib e rs w e re serio u sly d a m a g e d in S T Z 一D M g ro u P ，b u t in T P 一D M g ro u P th e d a m a g e s w e re o b v io u sly le sse n e d . W e o b se rv e d th e m o r p h o u s o f le n s e e lls th ro u g h H E d y e in g a n d f ou n d th a t th e re w e re a g re a t d e a l o f e e ll o rg a n e lle s h a d n o t d e g ra d e d in e ry sta llin e f ib er e e lls o f S T Z 一D M g ro u P ，a n d th e re g io n w ith n o e e ll o rg a n e lle sh ra n k . N e v e r th e le ss，w e o b se rv e d th e re v e rse re su lts in T P 一D M g ro u P .T h e a c tiv ity o f C A T a n d th e e o n te