dna修复酶基因ogg1 xrcc1和ape1的多态性与老年性白内障的相关性研究word格式论文.docxVIP

dna修复酶基因ogg1 xrcc1和ape1的多态性与老年性白内障的相关性研究word格式论文.docx

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dna修复酶基因ogg1 xrcc1和ape1的多态性与老年性白内障的相关性研究word格式论文

独创性声明本人声明所呈交的学位论文是我个人在导师指导下进行的研究工作及取得的研究成果。尽我所知,除文中已经标明引用的内容外,本论文不包含任何其他个人或集体已经发表或撰写过的研究成果。对本文的研究做出贡献的个人和集体,均已在文中以明确方式标明。本人完全意识到本声明的法律结果由本人承担。学位论文作者签名:日期:年月日学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定,即:学校有权保留并向国家有关部门或机构送交论文的复印件和电子版,允许论文被查阅和借阅。本人授权华中科技大学可以将本学位论文的全部或部分内容编入有关数据库进行检索,可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文。本论文属于保密□,在年解密后适用本授权书。不保密□。(请在以上方框内打“√”)学位论文作者签名:指导教师签名:日期:年月日日期:年月日目录中文摘要·······························································································1ABSTRACT 2前言··································································································4材料与方法····························································································6结果·································································································11讨论································································································15结论································································································17参考文献·····························································································18综述································································································22附录英文缩略词表·············································································35致谢································································································36DNA修复酶基因OGG1、XRCC1和APE1的多态性与老年性白内障的相关性研究硕士研究生:王琛导师:胡军副教授华中科技大学同济医学院附属同济医院眼科中文摘要【目的】本试验主要研究8-羟基鸟嘌呤糖苷酶-1(OGG1)、X射线交错互补修复酶-1(XRCC1)和AP核酸内切酶-1(APE1)的单核苷酸多态性与老年性白内障发病风险之间的相关性。【方法】通过PCR-聚合酶链式反应和单向测序,我们检测了402 个白内障病人和813 个健康对照组人群的基因型。用卡方检验来评估频率差异,用二分类logistic回归分析来计算患病风险。【结果】APE1-141G/G基因型在病例组和对照组之间存在显著的差异(P=0.002)。进行了年龄和性别的校正后这种差异仍然存在(P*=0.003)。白内障患者中T/T基因型的频率明显高于对照组,而G/G基因型和G等位基因的频率明显低于对照组(P值均小于0.05)。而对OGG1Ser326Cys 和XRCC1Arg399Gln 的基因多态性研究没有观察到等位基因和基因型频率在对照组和患者中存在统计学差异。【结论】APE1 -141 G/G 基因型可能起着阻断白内障形成的保护作用(OR,0.49;95%CI,0.31–0.77),而T等位基因则可能作为一个危险因素促进老年性白内障的发展;同时在OGG1 Ser326Cys和XRCC1Arg399Gln的基因多态性研究中未发现等位基因和基因型频率在对照组和病例组中的差异。

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