egcg激活nrf2are通路对液压冲击脑损伤的神经保护作用及其机制word格式论文.docxVIP

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egcg激活nrf2are通路对液压冲击脑损伤的神经保护作用及其机制word格式论文.docx

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egcg激活nrf2are通路对液压冲击脑损伤的神经保护作用及其机制word格式论文

目录中文摘要···········································································································1英文摘要···········································································································5英文缩写·········································································································10研究论文EGCG激活Nrf2-ARE通路对液压冲击脑损伤的神经保护作用及其机制前言··········································································································11材料与方法······························································································13结果·········································································································24附图··········································································································27附表··········································································································42讨论··········································································································47结论··········································································································52参考文献··································································································53综述EGCG 抗氧化性质及其对中枢神经系统疾病的保护作用57致谢··············································································································71个人简历··········································································································72EGCG激活Nrf2-ARE通路对液压冲击脑损伤的神经保护作用及其机制摘要目的：通过观察表没食子儿茶素没食子酸酯（EGCG）对液压冲击脑损伤后核因子E2相关因子2（Nrf2）、caspase-3、caspase-12及炎性细胞因子表达变化的影响，探讨EGCG在液压冲击脑损伤所发挥的抗凋亡、抗炎的神经保护作用及其机制。方法：1体重为250g±50g的成年雄性SD大鼠24只，随机分成3组：假手术组（ShamGroup）、脑损伤溶媒组（TBI+VehicleGroup）以及脑损伤干预组（TBI+EGCGGroup），每组8只。后两组均实施麻醉后，于颅骨矢状缝右侧、冠状缝后约5mm处磨取骨窗，直径约4mm，常规行液压冲击，其中TBI+Vehicle组磨骨窗、液压冲击后给予腹腔注射生理盐水1ml，TBI+EGCG组磨骨窗、液压冲击后给予腹腔注射EGCG50mg/kg+1ml生理盐水；Sham组大鼠常规麻醉后，头颅磨除骨窗，保持硬膜完整，但不行液压冲击伤。2所有动物在24h进行mNSS神经功能缺损评分，并过度麻醉，断头处死后迅速开颅取出脑组织。在大鼠脑组织损伤区前部切取大约100mg，应用E