HCG及PLF水平与胎儿发育迟缓的相关研究.docVIP

HCG及PLF水平与胎儿发育迟缓的相关研究 【摘要】 目的探讨孕妇血浆绒毛膜促性腺激素（HCG）及胎盘异铁蛋白（PLF）水平与胎儿宫内发育迟缓(IUGR)发生、发展的关系。方法 对晚孕早期（孕24～34周）最初正常的1 802例孕妇，根据随访妊娠结局分为IUGR组(64例)，用化学发光法进行血浆绒毛膜促性腺激素和胎盘异铁蛋白的水平测定，并与正常组（50例）对比分析。结果IUGR组β-HCG为(50.63±8.86)μg/L较正常组(18.76±3.69)μg/L明显升高；而PLF(242.76±43.69)mg/L低于正常组（716.95±82.63)mg/L，差异有统计学意义（P0.01）；绒毛膜促性腺激素与胎盘异铁蛋白水平呈负相关（r= -0.563,P0.01）。结论晚孕早期绒毛膜促性腺激素水平升高和胎盘异铁蛋白水平的降低与胎儿宫内发育迟缓的发生有密切关系。 【关键词】 绒毛膜促性腺激素; 胎盘异铁蛋白; 胎儿宫内发育迟缓 Correlation of levels of human chorionic gonadotropin and placental isoferritin with pathogenesis of Intrauterine fetus growth retardation. LIANG Yi-bo, HUANG Si-yi, MO Wei, et al. (Zhanjiang Municipal Second People Hospital, Zhanjiang 524003 , Guangdong ,P.R.China) Abstract：Objective To discusses the correlation of levles of blood human chorionic gonadotropin (HCG) and the placental isoferritin (PIF) in pregnant women with intrauterine growth retardation (IUGR) of fetus. Methods There 1 802 normal pregnant women with gestational duration of 24-34 weeks weere, based on outcome of gestation, divided into IUGR group consisted 64 cases and the levels of HCG and PIF were determined with chemiluminescence and the results were compared with the controlsconsited of 50 cases. Results The level ofbeta;-HCG in IUGR group was (52.63±8.86)mu;g/L, significantly higher than that of normal group (18.76±3.69)mu;g/L); But the level of PLF was 242.76±43.69 mg/L, lower than that of the normal group ((716.95±82.63 )mg/L), showing significant difference (P0.01). Conclusion The increase of level of early bloodbeta;-HCG and the decrease of the level of PIF at late genstional period is associated with the occurrence of intrauterine growth retardation o fetus. Key words：Human chorionic gonadotropin; Placental isoferritin; Intrauterine growth retardation 胎儿宫内发育迟缓（IUGR）是围生期主要并发症之一，也是围生儿死亡的重要原因之一，其发生率一般为3%～7%,我国的平均发生率为6.39%。IUGR的围生儿病死率为正常体重儿的4～6倍，且影响婴儿以后体格和智力的发育。其发生机制尚未完全阐明，而母儿免疫耐受机制的异常与胎儿宫内发育迟缓的发病有密切关系［1］。本研究对晚孕早期（孕24～34周）最初正常的1 802例孕妇，根据随访妊娠结局为IUGR的64例，用化学发光法进行血浆绒毛膜促性腺激素（b