g蛋白偶联嘌呤受体p2y2p2ry2)基因与心脑血管疾病的相关性研究-correlation between g protein-coupled purine receptor p2y2 p2 ry 2 ) gene and cardiovascular and cerebrovascular diseases.docxVIP

g蛋白偶联嘌呤受体p2y2p2ry2)基因与心脑血管疾病的相关性研究-correlation between g protein-coupled purine receptor p2y2 p2 ry 2 ) gene and cardiovascular and cerebrovascular diseases.docx

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g蛋白偶联嘌呤受体p2y2p2ry2)基因与心脑血管疾病的相关性研究-correlation between g protein-coupled purine receptor p2y2 p2 ry 2 ) gene and cardiovascular and cerebrovascular diseases

新疆医科大学医学博士学位论文(P=0.006), with the frequency of the T-A-G haplotype significantly higher, while the T-C-G haplotype significantly lower for the EH patients as compared to the controls (P=0.001 and P=0.014, respectively); 3) In the third part of association study about CI, among women, the distribution of the dominant rs4944832 phenotype (GG vs. GA+AA) differed significantly both between the CI patients and the control 1 (P=0.043) and between the CI patients and the control 2 (P=0.029). Logistic regression analysis showed that the GG genotype of rs4944832 was significantly more prevelant in the female CI patients than in the control 1 (P=0.021) and in the control 2 (P=0.005). For all subjects, the overall distribution of the haplotype established by SNP2-SNP4-SNP5 was significantly different between the CI patients and the control 1 (P=0.027). For all subjects, the frequency of the T-A-G haplotype (SNP2-SNP4-SNP5) was also significantly higher (P=0.031), while the frequency of the T-C-G haplotype (SNP2-SNP4-SNP5) was significantly lower (P=0.029) in the CI patients than in the control 1. Conclusions: The present results indicate that the GA+AA genotype of ralong with the C-A and T-C-A haplotypes of the human P2RY2 gene could be genetic markers for MI in Japanese men. Furthermore, rs4944831 and the T-A-G haplotype of the human P2RY2 gene might be genetic markers for EH in Japanese men. Additionally, the T-A-G haplotype of the human P2RY2 gene may be a susceptibility haplotype for CI in Japanese subjects, and the GG genotype of rs4944832 may be a genetic marker for CI, particularly in Japanese women.Key words: P2RY2 gene;Cardio-cerebrovascular diseases; Single nucleotide polymorphisms—4—中英文缩略词对照表英文缩写英文全名中文译名P2RY2Purinergic receptor P2Y, G-protein coupled, 2 G 蛋白偶联嘌呤受体 P2Y2ATPAdenosine triphosphate三磷酸腺苷UTPUridine triphosphate三磷酸尿苷SNPSingle nucleotide polymorphism单核苷酸多态性VSMCVascular smooth muscle cells血管平滑肌细胞MIMyocardial infarction心肌梗死EHEssential hypertension原发

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