hbx蛋白介导的自噬在肝癌多药耐药中的作用及机制分析-role and mechanism of hbx protein-mediated autophagy in multidrug resistance of hepatocellular carcinoma.docxVIP

The HBX protein-mediated autophagy effects and mechanisms of multidrug resistanceAbstractHepatic carcinoma is one of the common and high malignancy malignant tumors in China. Chemotherapy is an important treatment for liver cancer, but hepatic carcinoma is prone to be multidrug resistance (multidrug resistance, MDR). In the pathogenesis of HCC, hepatitis B virus (HBV) infection is an important factor in the occurrence of hepatocellular carcinoma. Hepatitis B virus HBX gene integrated into the host cell as a function of the important gene, is the important factor that influences the biological characteristics of hepatocellular carcinoma. Previous studies have shown that HBX-mediated and involved in hepatic carcinoma multidrug resistance. But at the same time we also found that apoptosis is not the only way of liver cancer cell death regulation of apoptosis level not full intervention in hepatoma cell MDR. Therefore, we need to explore further from the point of view of non-apoptotic to find new possible mechanism for HBX induced liver cancer cells resistant to the comprehensive interpretation of the molecular mechanisms of HCC MDR. Autophagy as eukaryotic cells that are peculiar for the phenomenon of life, has proved its participation in tolerance regulation of tumor cells to chemotherapeutic agents. The tumor cells by autophagy protective to exclude damaged proteins or organelles, isolation of hazardous substances, to speed up the circulation of macromolecules, leading to tumor cells expressing the resistance phenotype. The body through this a special way to maintain the stability of the internal environment. Signal pathway existence peripheral environment changes within cells, G interference (G α -interacting α protein protein, GAIP) as essential autophagy regulation upstream protein involved in the regulation of autophagy, changes of tumor cells.Therefore, we need to further explore the the HBX protein is mediated Gα interfere with protein ex