hsp90抑制剂对白念珠菌刺激巨噬细胞增殖和p38mapk表达的影响-effects of hsp 90 inhibitor on macrophage proliferation and p 38 mapk expression stimulated by candida albicans.docx

目录中文摘要·················································································································1 英文摘要·················································································································5 英文缩写···············································································································11 研究论文 HSP90 抑制剂对白念珠菌刺激巨噬细胞增殖和 p38MAPK 表达的影响 前言···············································································································12 材料与方法··································································································14 结果···············································································································22 附图···············································································································24 附表···············································································································28 讨论···············································································································30 结论···············································································································34 参考文献·······································································································35综述 HSP90 抑制剂在炎性疾病中的应用 39致谢························································································································53 个人简历···············································································································54HSP90 抑制剂对白念珠菌刺激巨噬细胞增殖和 p38MAPK 表达的影响摘要目的：炎症反应是宿主抵抗病原体的一个重要反应途径，然而，当炎 症过度活化或失去调节时，将导致宿主的组织损伤。大量实验证实：过度 活化的炎性细胞因子介导的固有免疫和适应性免疫能够导致人类脓毒血 症以及免疫功能障碍的发生。在临床中，念珠菌血症具有一些同细菌性脓 毒血症相似的症状。早期大部分表现为中高热、低血压、心率增快以及酸 中毒等症状，而晚期一些患者常发展为感染性休克以及多器官功能障碍。 促分裂原活化蛋白激酶（MAPK）家族在炎症和应激中是信号转导重要的 组成部分，能够调控一系列的生理过程。MAPK 家族包括 p38,JNK,和 ERK, 并 通 过 磷 酸 化 激 活 。 有 研 究 显 示 , 在 细 菌 性 脓 毒 血 症中 p-p38,p-ERK,p-JNK 的表达显著增加，而 MAPK 的磷酸化可导致器官的 损伤。此外，p38 的激活能够调节巨