雷公藤红素对人胆管癌 tfk1细胞株抑制作用的实验研究-experimental study on the inhibitory effect of tripterine on tf k1 cell line of human cholangiocarcinoma.docxVIP

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雷公藤红素对人胆管癌 tfk1细胞株抑制作用的实验研究-experimental study on the inhibitory effect of tripterine on tf k1 cell line of human cholangiocarcinoma.docx

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雷公藤红素对人胆管癌 tfk1细胞株抑制作用的实验研究-experimental study on the inhibitory effect of tripterine on tf k1 cell line of human cholangiocarcinoma

独创性声明本人郑重声明，本学位论文是本人在导师指导下进行的研究工作及取得的研究成果的总结。尽我所知，除文中已经标明引用的内容外，本论文不包含任何其他个人或集体已经发表或撰写过的研究成果。对本文的研究做出贡献的个人和集体，均已在文中以明确方式标明。本人完全意识到本人将承担本声明引起的一切法律后果。学位论文作者签名：日期：年月日学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，即：学校有权保留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本人授权华中科技大学可以将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文。本论文属于保密□，在年解密后适用本授权书。不保密□。（请在以上方框内打“√”）学位论文作者签名：指导教师签名：日期：年月日日期：年月日本实验研究受科技部国际科技合作项目资助(项目编号：2010DFA31870）目录英文缩略词表·················································································2前言···························································································4中文摘要························································································7ABSTRACT10第一部分雷公藤红素对胆管癌细胞增殖和细胞周期的影响··········14材料与方法······································································14结果············································································19讨论············································································22第二部分雷公藤红素对胆管癌细胞凋亡及其相关蛋白表达的影响25材料与方法······································································25结果············································································30讨论············································································32第三部分雷公藤红素对胆管癌荷瘤鼠抗肿瘤作用及机制初探·······36材料与方法······································································36结果············································································40讨论············································································44全文总结·······················································································50综述雷公藤红素的抗炎及抗肿瘤作用分子靶向研究进展··········51参考文献·······················································································69附录1攻读学位期间发表论文··················································91附录2攻读学位期间参加的学术会议········································92致谢··························································································93英文缩略词表英文缩写英文全称中文全称CCACholangiocarcinoma胆管细胞型肝