血清TRAb动态监测在Graves病131I治疗中应用.docVIP

血清TRAb动态监测在Graves病131I治疗中应用 　　【摘要】目的:探讨血清TRAb动态监测在Graves病131I治疗中的应用价值。方法:350例Graves病患者和135名健康对照者分别于131I治疗前及治疗后3,6,9和12个月采用放射受体分析法（RRA）测定其TRAb水平。将治疗前TRAb水平与对照组、治疗后3个月与治疗前、治疗后6,9,12个月与对照组比较。结果:患者组血清TRAb水平治疗前〖（84.57±41.42）U/L〗明显高于健康对照组〖（7.86±13.18）U/L, P＜0.01〗；治疗后3个月〖（62.21±28.51）U/L〗明显低于治疗前（P＜0.01）；治疗后6 〖（43.14±28.82）U/L〗，9 〖（16.88±12.32）U/L〗和12 〖（14.42±12.36）U/L〗个月逐渐下降，但仍明显高于对照组（P＜0.01）。 结论:血清TRAb动态监测有助于Graves病的诊断和131I治疗后的随访监测和疗效评价。 　　【关键词】Graves病；促甲状腺激素受体抗体；动态监测；131I治疗 　　【中图分类号】R743.34 【文献标识码】A 【文章编号】1008-6455（2011）12-0099-01 　　Application of Dynamic Monitoring of Serum TRAb after sup131I Radiotherapy in Patients of Graves Disease 　　Li Sanxi 　　【Abstract】Objective:To explore the application value of dynamic monitoring of serum thyrotrophin receptor antibody （TRAb） after 131I radiotherapy in patients of Graves disease. Methods:A total of 350 patients with Graves disease and 135 normal controls were included in the study. Serum concentration of TRAb was measured by radioreptor assy （RRA） before and at 3,6,9 and 12 months after 131I radiotherapy. It were compared to TRAb concentration between before the treatment and control group, 3 months and before the treatment as well as 6,9,12 months and control group. Results:TRAb level 〖（84.57±41.42）U/L〗 before treatment in Graves disease group was obviously high than that of control group 〖（7.86±13.18）U/L, P＜0.01〗. TRAb level 〖（62.21±28.51）U/L〗 after treatment was obviously low than that of before treatment（P＜0.01）. Although it dropped to （43.14±28.82）U/L, （16.88±12.32）U/L and （14.42±12.36）U/L at 6,9 and 12 months respectively after treatment, above TRAb levels were high than that of control group（P＜0.01）. Conclusion:Dynamic monitoring of serum TRAb is of clinical significance in the diagnosis of Graves disease and in the monitoring and efficacy evaluation of 131I radiotherapy. 　　【Key words】Graves disease；Thyrotrophin Receptor Antibody （TRAb）；Dynamic monitoring；131I radiotherapy 　　弥漫性甲状腺肿伴甲状腺功能亢进（Graves病）是一种常见的自身免疫性疾病，