7糖肽类、噁唑烷酮类和磷霉素类.pptVIP

利奈唑胺不良事件 利奈唑胺耐药机制 菌种 S.aureus S.epidermidis S.haemolyticus E.faecalis E.faecium S.aureus S.epidermidis S. pneumoniae 耐药机制 Mutations in 2 or more 23S rRNA gene copies G2576T; T2500A G2576T; G2603T; C2534T; T2504A G2576T G2576T G2576T Acquisition of Cfr methyltransferase; Mehtylates adenosine 2503 in 23S Rrna (PhLOPS phenotype) Mutations in riboprotein L4 交叉耐药 Pleuromutilins Chloramphenicol Lincosamides Pleuromutilins Streptogramin A Macrolides Chloramphenicol 0.40 % 2002-2005 2006 2007 2008 利奈唑胺耐药情况2004-2008 1.00