百令胶囊合雷公藤多甙片对iga肾病小鼠tgf-β1表达特征的影响-effects of bailing capsule combined with tripterygium wilfordii polyglycoside tablets on tgf - β 1 expression in iga nephropathy mice.docxVIP

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百令胶囊合雷公藤多甙片对iga肾病小鼠tgf-β1表达特征的影响-effects of bailing capsule combined with tripterygium wilfordii polyglycoside tablets on tgf - β 1 expression in iga nephropathy mice.docx

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百令胶囊合雷公藤多甙片对iga肾病小鼠tgf-β1表达特征的影响-effects of bailing capsule combined with tripterygium wilfordii polyglycoside tablets on tgf - β 1 expression in iga nephropathy mice

EffectofBailingcapsulecombinedTripterygiumwilfordiitabletsonserumTransforminggrowthfactor-β1expressioncharacteristicsinIgAnephrosisinmiceABSTRACTObjective:ToobservetheeffectofBailingcapsulecombinedTripterygiumwilfordiitabletsonserumTransforminggrowthfactor-β1expressioncharacteristicsinIgAnephrosisinmiceandtoexploreitsmechanism.Methods:60Kunmingfemalemice,preparedas9fortheaccidentaldeath,check8randomforthenormalcontrolgroup,othermiceofgavagebovineserumalbuminplussubcutaneousinjectionofcarbontetrachloridemodeloftheestablishmentofIgAnephropathy.Confirmedthesuccessfulmodel,wererandomlydividedintomodelgroup,Bailingcapsulegroup,Tripterygiumwilfordiitabletsgroup,togetherBailingcapsuleTripterygiumwilfordiitabletshigh-dosegroup,BailingcapsuleTripterygiumwilfordiitabletstogetherdosetablets,capsulesBailingTripterygiumwilfordiitabletslow-dosegroupwere6groupswith7mice.Observationofurine,24hurinaryprotein,changesinliverandrenalfunction,observethechangesofserumTGF-β1.Results:1.Modelmodel100percentsuccessrate.2.24hurinaryprotein:Pre-treatmentmodelgroupandtreatmentgroupmore24hUProquantitativethannormalgroup(P0.05),themodelgroupandtreatmentgroup24hUProquantitativelysimilar(P0.05).Aftertreatment,treatmentgrouplower24hUProquantitativethanmodelgroup(P0.01),togetherBailingcapsulecombinedTripterygiumwilfordiitabletshighdosegroupdoesthebesttreatmentinwhichthetreatmentgroupcompared(P0.05).3.Microscopichematuria:AftertreatmentthemicroscopichematuriadisappearedofBailingcapsulecombinedTripterygiumwilfordiitabletsinhighanddosegroup(-),themicroscopichematuriareducedofcombinedlow-dosegroupandBailingcapsulegroupandTripterygiumwilfordiitabletsgroup(+~++).4.Renalfunction:treatmentgroupbloodScrleverwerelowerthanthemodelgroup(P0.05),togetherBailingcapsulecombinedTripterygiumwilfordiitabletsinhighanddosegroupissimilartonormalgroup(P0.05);togetherBailingcapsulecombinedTripterygiumwilfordiitabletsthebiggestchangesinhighanddosegroupinwhichthetreatmentgroupcompared(P0.05).BUNbloodtocompareeachgroup,nostati