桥本甲状腺炎患者血清25-ohd3 水平和th1th2细胞因子失衡的相关性研究-correlation between serum 25 - ohd _ 3 level and th1st _ 2 cytokine imbalance in hashimotos thyroiditis patients.docxVIP

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桥本甲状腺炎患者血清25-ohd3 水平和th1th2细胞因子失衡的相关性研究-correlation between serum 25 - ohd _ 3 level and th1st _ 2 cytokine imbalance in hashimotos thyroiditis patients.docx

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桥本甲状腺炎患者血清25-ohd3 水平和th1th2细胞因子失衡的相关性研究-correlation between serum 25 - ohd _ 3 level and th1st _ 2 cytokine imbalance in hashimotos thyroiditis patients

目录中文摘要···········································································································1 英文摘要···········································································································3 英文缩写···········································································································6 研究论文桥本甲状腺炎患者血清 25-（OH）D3 水平和 Th1/Th2 细胞因子失衡的相关性研究前言···········································································································7材料与方法·······························································································8结果··········································································································12 附表··········································································································15讨论··········································································································17结论··········································································································20 参考文献··································································································21综述桥本甲状腺炎患者中维生素 D 与辅助性 T 细胞失衡 24致谢··················································································································33个人简历··········································································································34桥本甲状腺炎患者血清 25-（OH）D3 水平和 Th1/Th2 细胞因子失衡的相关性研究摘要目的：桥本甲状腺炎（HT），是内分泌科比较常见的甲状腺疾病，近些年发病率逐年攀升，影响患者生存质量。但其病因目前尚不十分明确，根据现有的资料显示，Th1、Th2 和 25-（OH）D3 在 HT 的发病过程中都有重要作用。Th1、Th2 通过调控细胞因子的分泌来影响甲状腺，25-（OH） D3 通过影响细胞免疫和体液免疫来影响甲状腺。但 Th1/Th2 失衡与 25-（OH）D3 是否存在相关性，目前尚未见此类报道。此外，Th1/Th2 细胞因子在 HT 中的地位如何，目前有一些研究仍存争议。本实验将以 HT 为研究对象，25-（OH）D3 、Th1/Th2 因子和甲状腺功能为研究内容，对他们之间的相互关系进行相应探讨。方法：本实验将研究对象分为两组，一组为 HT 组（病例组），另一组为健康对照组（对照组），研究对象为符合入组条件的初诊 HT 甲减患者及健康对照者。所有研究对象均抽取晨起空腹静脉血来检测 s-TSH， FT3，FT4，TPOAb，TGAb，IL-2，IL-4，IL-6，IL-10，IFN-γ，25-（OH）D3。所有数据均应用 SPSS 17.0 软件进行统计分析，采取双侧性检验，以P0.05 视为差异有统计学意义。结果：1