运动训练对核转录因子kappaB信号通路及炎性基因影响研究进展.docVIP

运动训练对核转录因子kappaB信号通路及炎性基因影响研究进展 　　摘要：NF-κB(核转录因子-kappaB)信号通路在机体的免疫应答、细胞增殖、凋亡和生长发育中发挥重要作用。运动训练过程中机体产生的活性氧以及运动性肌肉损伤激活了NF-κB信号通路，对NF-κB活性的影响与运动训练的持续时间、频率和强度有关。急性剧烈运动导致了NF-κB活性一过性提高；长期有规律的运动训练能够降低由于衰老和慢性炎症反应而上调的NF-κB的活性；长期剧烈的运动训练导致了NF-κB的慢性持续激活，使通路上各指标的表达发生变化，细胞核中聚集NF-κB的亚基p65浓度增多，转录靶基因，从而使炎性基因的表达大幅度升高，一方面放大机体固有免疫系统对抗运动性应激，另一方面参与了骨骼肌运动性慢性炎症的形成。 　　关键词：运动生物化学；核转录因子-kappaB；核转录因子-kappaB抑制蛋白激酶；氧化应激；运动训练；综述 　　中图分类号：G804.7文献标识码：A文章编号：1006-7116(2011)03-0140-05 　　 　　Progress in the study of the effects of sports training on the signal channel and 　　inflammatory gene of nuclear transcription factor kappaB 　　CHEN Yan-mei1，2，HAO Xuan-ming1 　　（1.School of Physical Education，South China Normal University，Guangzhou 510006，China； 　　2.School of Physical Education，South West University，Chongqing 400700，China） 　　 　　Abstract: The signal channel of NF-κB (nuclear transcription factor kappaB) plays an important role in immune response as well as cell proliferation, apoptosis and development of the body. Active oxygen and kinetic muscle damage produced by the body during sports training activate the typical signal channel of NF-κB. The effect of NF-κB activity is related to the duration, frequency and intensity of sports training. Acute strenuous exercising causes the one time increase of NF-κB activity; long term regular sports training can lower NF-κB activity increasing as a result of aging and chronic inflammatory reaction; long term strenuous sports training results in the chronic, continuous activation of NF-κB, the changing of expression of various indexes on the channel, the increase of the concentration of subunit p65 of NF-κB aggregating in nucleus and transcription target genes, thus significantly increases the expression of inflammatory genes; on the one hand, it amplifies the exercise resisting stress of the intrinsic immune system of the body, while on the other hand, it participates in the formation of kinetic chronic inflammation of skeletal muscle. 　　Key words: e