阿伐他汀对颈动脉粥样硬化斑块稳定性研究.docVIP

阿伐他汀对颈动脉粥样硬化斑块稳定性研究 　　（泸州市人民医院神经内科 四川 泸州 646000） 　　 　　【摘要】目的: 探讨阿伐他汀对脑梗死患者颈动脉粥样硬化斑块及血脂的影响。方法: 将经彩色多普勒超声发现颈动脉粥样硬化斑块的140例脑梗死患者随机分成治疗组（80例）和对照组（60例）, 治疗组给予阿伐他汀20 mg /d, 治疗6 个月。对照组采用饮食控制或服非他汀类药物。分别于入院时、治疗后检测两组粥样斑块大小，颈动脉内膜中层厚度（IMT）和血脂、纤维蛋白原、肝肾功能、肌酸磷酸激酶。结果: 80例患者经阿伐他汀治疗6个月后粥样硬化斑块的IMT由1.87±0.25降为1.32±0.22mm，下降幅度为29.95%,与对照组比较差异有统计学意义（p?0.01）.治疗组TC、TG、LDL与用药前明显下降。结论: 阿伐他汀通过降低LDL-C、拮抗炎症反应等，可稳定、逆转颈动脉粥样硬化斑块，减少脑卒中的发生及再发。 　　【关键词】 阿伐他汀; 颈动脉粥样斑块;稳定性；脑梗死 　　 　　Study of atorvastatin on carotid atherosclerosis plaque stability 　　 Jiang Hua 　　【Abstract】 ObjectiveTo investigate the effect of atorvastatin on carotid atheroscleroticplaque and blood lipidinpatients with cerebral infarction .MethodsDivide the 140 cases, in which carotid atherosclerosis plaque have been foundwith Color Doppler ultrasound, randomly into treatment group （80 Cases ）,and comparison group （60 cases ）. Treatment group uses atorvastatin 20 mg /d, with treatment period of 6 months. Comparison group applies the strategy of controlling the amount of food intake or taking orther medications rather than atorvastatin medication. Test the Atheroma size, carotid artery intima-media thickness （IMT）和blood lipid、liver and kidney function andFibrinogen and creatine phosphokinase. in two groups before and after the treatment. Results The patients in 80 cases treated with atorvastatinwith 6 months have the TMT of the Atheroma drops from1.87±0.25 to 1.32±0.22mm, and so the decreasing percentage is about 29.95%, compared with comparison group differences are statistically significant （p?0.01）. The values of TC, TG and LDL, in the treatment group, have decreased significantly, comparing to the results obtained before the treatment. Conclusionby reducing the values of LDL-C、antagonism to inflammatory response, etc.,atorvastatincan help to cure the desease of Atheroma and minimise the reoccuring chance ofstroke. 　　【Key words】 Atorvastatin; Carotid artery plaque ; Stability : cerebral infarction 　　【中图分类号】R339【文献标识码】B【文章编号】1