Lp(a)hs-CRPFib与冠心病相关性研究.docVIP

Lp(a)hs-CRPFib与冠心病相关性研究 　　[摘要] 目的 探讨脂蛋白（a）、高敏C反应蛋白、纤维蛋白原与冠心病的相关性。 方法 冠心病36例确诊患者，分为稳定型心绞痛组、不稳定型心绞痛组和急性心肌梗死组，所有患者均于清晨空腹抽静脉血行Lp（a）、hs-CRP、Fib检测，并以12例健康者作为对照组。 结果 冠心病各组Lp（a）、hs-CRP、Fib含量较正常对照组均显著升高，急性心肌梗死组、不稳定型心绞痛组，较稳定型心绞痛组各项指标含量均明显升高，差异有统计学意义。 结论 Lp（a）、hs-CRP、Fib与冠心病密切相关，对观察冠心病的严重程度和演变情况具有重要的临床意义。 　　[关键词] 脂蛋白（a）；高敏C反应蛋白；纤维蛋白原；冠心病 　　[中图分类号] R541.4[文献标识码] B[文章编号] 1673-9701（2012）10-0056-02 　　Study of the relationship between Lipoprotein (a) and high-sensitivity C-reactive protein and fibrinogen with coronary heart disease 　　WANG Wenyuan AN Sucai 　　Department of Cardiology， the People’s Hospital of Puyang City in Henan Province，Puyang 457001，China 　　[Abstract] Objective To investigate the relationship between Lipoprotein (a) and High-sensitivity C-reactive Protein (hs-CRP) and Fibrinogen (Fib) with Coronary Heart Disease (CHD). Methods 36 cases of diagnosed CHD patients, were divided into stable angina pectoris group, unstable angina pectoris group and acute myocardial infarction group. The fasting blood of all patients were used to detect the level of Lp (a), hs-CRP, Fib. 12 healthy persons were as controls. Results Lp (a), hs-CRP, Fib level in each CHD group compared with normal control group were significantly elevated, each index in acute myocardial infarction and unstable angina group than that in stable angina group were significantly higher. Conclusion The level of Lp (a), hs-CRP and Fib has a close relationship with CHD, which has important clinical significance to observe the severity and evolution of CHD. 　　[Key words] Lipoprotein (α); High-sensitivity C-reactive protein; Fibrinogen; Coronary heart disease 　　冠心病（coronary heart disease，CHD）是指冠状动脉粥样硬化使血管腔狭窄或阻塞，或因冠状动脉功能性改变导致心肌缺血缺氧或坏死而引起的心脏病，是严重危害人类健康的常见病，其发病率近年来呈增长趋势。脂蛋白（a）[Lp（a）]升高与冠心病、脑卒中等动脉粥样硬化性疾病密切相关，为冠心病的独立危险因素[1]。高敏C反应蛋白（hs-CRP）和纤维蛋白原（Fib）是机体炎症反应的敏感标志物，与冠心病关系密切[2]。本研究旨在探讨脂蛋白（a）、高敏C反应蛋白、纤维蛋白原与冠心病的相关性，以提高对冠心病的诊断和冠脉病变严重程度的判定。 　　1 资料与方法 　　1.1 一般资料 　　冠心病组：选取我院2011年1~ 9月收住院的冠心病患者36例，均符合冠心病的诊断标准，并排除其它疾病。