高血压及相关危险因素对老年认知功能影响-effect of hypertension and related risk factor on cognitive function in elderly people.docxVIP

上海交通大学医学院硕士论文上海交通大学医学院硕士论文IVIVanalysis.Results: 1.The MoCA scores of total score, subscores of visuospatial and executive, attention, language, delayed recall were significantly decreased in hypertensive group (P0.05). The MMSE scores of two groups had no significantly difference (P0.05). 2.24hMDBP,dMDBP and the proportion of normal circadian rhythm were significantly increased in hypertensive patients whose MoCA scores were normal (P0.01). There were no significant differences in the parameters of ambulatory blood pressure between the normal MMSE score group and the lower MMSE score group (P 0.05). The proportion of lower MMSE scores was significantly increased in the patients who had hypertensions and strokes (P0.05). 3.The MoCAscores＝26.860-0.110age+8.449circadian rhythm+0.069dMDBP. The MMSEscores＝36.231-0.074age-0.387 TG-0.037 nMDBP。Conclusions: 1.The hypertensive group had lower MoCA scores in total score, subscores of visuospatial and executive, attention, language, delayed recall. The MMSE scores of two groups had no significantly difference. MoCA is sensitive in clinical assessment of cognitiveimpairment．2. The data suggested that age, circadian rhythm and dMDBPappeared to be independent variables for predicting the MoCA scores in patients with hypertension. Age was negative linear correlation with the PAGE PAGE VIMoCA scores. Circadian rhythm and dMDBP were positive linear correlation with the MoCA scores.3.The data suggested that age, TG and nMDBP appeared to be independent variables for predicting the MMSE scores in patients with hypertension. All the variables were negative linear correlation with the MMSE scores. The MMSE scores were lower in the patients who had hypertensions and strokes.KEY WORDS: hypertension, elderly, cognitive function, risk factors，MoCA, MMSE符号说明英文缩写 中文全称MCI 轻度认知功能损害VCI 血管性认知功能障碍AD 阿尔茨海默病SBP 收缩压DBP 舒张压PP 脉压MoCA 蒙特利尔认知评估MMSE 简短精神状态检查TC 胆固醇TG 甘油三酯HDL-C 高密度脂蛋白胆固醇LDL-C 低密度脂蛋白胆固醇FBG 空腹血糖CCB 钙离子拮抗剂ACEI 血管紧张素转