高血压患者性别差异内皮功能障碍危险因素分析-analysis of risk factors for sex-differentiated endothelial dysfunction in hypertensive patients.docxVIP

目录目录IVIV目录第 1 章 引言 11.1 女性与高血压 21.2 血管内皮功能与高血压 21.3 女性与血管内皮功能 2第 2 章 资料与方法 ············································································ 42.1 研究对象 42.1.1 入选标准······································································· 42.1.2 排除标准······································································· 42.1.3 医学伦理······································································· 42.2 一般资料收集 52.3 无创内皮功能检测 52.4 统计分析 6第 3 章 结果 ····················································································· 83.1 一般资料比较 83.2 性别差异因素分析 93.3 内皮功能相关因素线性回归分析 11第 4 章 讨论 ···················································································· 154.1 传统心血管危险因素与内皮功能 154.2 同型半胱氨酸与血管内皮功能 164.3 雌激素与血管内皮功能 174.4 高密度脂蛋白-胆固醇与血管内皮功能 17第 5 章 不足之处 ·············································································· 19第 6 章 结论与展望 ··········································································· 206.1 结论 206.2 进一步的工作方向 20致 谢···························································································· 21 PAGE PAGE VI参考文献 ························································································ 22攻读学位期间的研究成果 ··································································· 28综 述 ····························································································· 29中英文中英文缩略词表中英文缩略词表缩略词CVD英文全称Cardiovascular disease中文全称心血管疾病FMDFlow mediated dilation血流介导的血管扩张功能SBPSystolic blood pressure收缩压DBPDiastolic blood pressure舒张压BMIBody mass index体质指数eGFREstimated glomerular filtration rete估计肾小球滤过率RHIReactive hyperemia index反应性充血指数OROdds ratio比值比CIConfidence interval可信区间HDL-CHigh-density lipoprotein高密度脂蛋白胆固醇LDL-CLow-density lipoprotein低密度脂蛋白胆固醇第 第 1 章 引言 PAGE PAGE 10第 1 章 引言以高血压、冠心病、脑卒中等为主的心血管疾病（cardiovascular disease, CVD）是威胁人类健康的主要疾病 [1]。然而，既往研究对女性心血管疾病缺乏 足够重视。同时，心血管疾病在女性具有知晓率低、治疗率低、控制率低等特 点，导致其预后不良 [2]。鉴于此，美国心脏协会倡导“go red for woman”运动， 呼吁关注女性心血管疾病。事实上，心血管疾病是导致女性死亡的首要因素 [1]。 同时，各种心血