硒对桥本甲状腺炎患者TPOAb及TGAb水平影响.docVIP

硒对桥本甲状腺炎患者TPOAb及TGAb水平影响 　　【摘要】 目的：观察硒对桥本甲状腺炎（HT）患者甲状腺过氧化物酶抗体（TPOAb）、甲状腺球蛋白抗体（TGAb）的影响。方法：选取TPOAb在100～600 IU/ml之间，TGAb在200 IU/ml到2000 IU/ml之间的HT患者66例，随机分为硒治疗组与对照组，硒治疗组（n=46）服硒酵母片（100 μg，2次/d）和左甲状腺素钠片（维持TSH至0.27～4.2 μIU/ml）治疗；对照组（n=20）服左甲状腺素钠片（维持TSH至0.27～4.2 μIU/ml）治疗，比较两组治疗3个月后TPOAb及TGAb水平的变化。结果：治疗3个月后两组TGAb水平与治疗前相比，差异无统计学意义（P0.05）。治疗3个月后，两组TPOAb水平明显降低，但降低值差异无统计学意义（P　　【关键词】 硒； 桥本甲状腺炎； 甲状腺过氧化物酶抗体； 甲状腺球蛋白抗体 　　The Effect of Selenium on Thyroid Peroxidase Antibody and Thyroglobulin Antibody in Hashimoto Thyroiditis/ZHANG Wei，WANG Jun-fang，LI Jing-li，et al.// Medical Innovation of China，2013，10（14）：013-014 　　【Abstract】 Objective：To observe the effect of selenium on thyroid peroxidase antibody（TPOAb） and thyroglobulin antibody（TGAb） in patients with Hashimoto thyroiditis（HT）.Method：66 patients with HT whose TPOAb levels were between 100 IU/ml and 600 IU/ml， TGAb levels were between 200 and 2000 IU/ml were randomized into selenium treatment group and control group.The selenium treatment group（n=46） received selenium yeast 200μg per day ，plus L-thyroxine to maintain TSH levels between 0.27-4.2 μIU/ml ；the control group received L-thyroxine to maintain TSH levels between 0.27-4.2μIU/ml.After 3 months compared the changes of TPOAb and TGAb levels in the two groups.Result：There were no significant changes of TGAb levels after 3 months of treatment compared with before treatment in the two groups（P0.05）.There were significant decrease of TPOAb levels after 3 months in the two groups，but the reduction had no significant difference between the two groups.Conclusion：Selenium has no significant effect on slightly increased TPOAb and TGAb levels in HT. 　　【Key words】 Selenium； Hashimoto thyroiditi； Peroxidase antibody； Thyroglobulin antibody 　　First-author’s address：Shanxi Medical University，Taiyuan 030001，China 　　doi：10.3969/j.issn.1674-4985.2013.14.007 　　桥本甲状腺炎是一种较常见的自身免疫性甲状腺炎。目前尚没有明确的方法来抑制免疫反应对甲状腺的破坏，主要治疗方法多采用左甲状腺素钠片维持甲状腺的功能。近年来，国内外有研究提出补硒治疗可降低HT患者TPOAb及TGAb水平，但也有研究显示硒对TPOAb及TGAb