不同他汀类药物治疗早发冠心病急性心肌梗死临床效果对比.docVIP

不同他汀类药物治疗早发冠心病急性心肌梗死临床效果对比 　　[摘要] 目的 观察不同他汀类药物治疗早发冠心病急性心肌梗死的效果。 方法 随机选取本院收治的150例诊断为早发冠心病急性心肌梗死的患者，根据治疗时口服的两类他汀类药物分为A、B组，A组口服瑞舒伐他汀，B组口服阿托伐他汀，同时设立75例常规治疗的患者为基础组。观察并记录治疗前及治疗6个月后所有患者超敏C反应蛋白（hs-CRP）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、左室射血分数（LVEF）、内皮舒张功能（FMD）的情况，对所得的数据进行统计学分析。 结果 治疗前后A组和B组各指标比较，差异无统计学意义（P0.05）；基础组治疗前后各指标差异无统计学意义（P0.05），治疗后A、B组各指标分别与基础组比较，差异有统计学意义（P＜0.05）。 结论 瑞舒伐他汀和阿托伐他汀治疗早发冠心病的效果显著，两种药物均可通过降低血脂、控制炎性反应，改善心室射血功能及调节血管内皮舒张功能。 　　[关键词] 早发冠心病；急性心肌梗死；瑞舒伐他汀；阿托伐他汀 　　[中图分类号] R541.4[文献标识码] A[文章编号] 1674-4721（2014）05（a）-0056-03 　　 　　Clinical effect contrast on different statin treatment of premature coronary heart disease and acute myocardial infarction 　　WANG Rui-hai 　　People′s Hospital of Nanao County in Guangdong Province,Nanao 515910,China 　　[Abstract] Objective To observe the effect of different statin treatment of premature coronary heart disease and acute myocardial infarction. Methods 150 patients with premature coronary heart disease and acute myocardial infarction in our hospital were randomly selected,they were divided into group A and group B according to the treatment of oral two classes of statins,group A was given rosuvastatin,group B was given atorvastatin,at the same time,set up 75 cases as the base group on the basis of conventional treatment.The hypersensitive c-reactive protein (hs-CRP),total cholesterol (TC),low-density lipoprotein cholesterol (LDL-C),left ventricular ejection fraction (LVEF),endothelial diastolic dysfunction (FMD) of patients before and 6 months after treatment were observed and recorded,the data for statistical analyzed. Results The indexes before and after treatment in group A and group B,there was no statistically significant difference (P0.05).The indexes before and after treatment in base group was no statistically significant difference (P0.05).The indexes after treatment in group A and group B compared with base group respectively,Based group there each index before and after the treatment,the difference was statistically significa