慢性缺氧和高脂饮食影响兔血浆中oxldl和lp-pla2表达及促动脉粥样硬化形成-chronic hypoxia and high fat diet affect the expression of ox ldl and lp - pla 2 in rabbit plasma and promote the formation of atherosclerosis.docxVIP

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2018-07-27 发布于上海
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慢性缺氧和高脂饮食影响兔血浆中oxldl和lp-pla2表达及促动脉粥样硬化形成-chronic hypoxia and high fat diet affect the expression of ox ldl and lp - pla 2 in rabbit plasma and promote the formation of atherosclerosis.docx

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慢性缺氧和高脂饮食影响兔血浆中oxldl和lp-pla2表达及促动脉粥样硬化形成-chronic hypoxia and high fat diet affect the expression of ox ldl and lp - pla 2 in rabbit plasma and promote the formation of atherosclerosis

group,plasmalevelsofLp-PLA2hadcertaindegreeinfluenceontheotherthreegroups(P0.05),amongwhich,At12thweekincreasedmostsignificantlyinLp-PLA2concentrations(P0.05).(2)Comparisonwithinthegroup:Exceptthe0thweekand4thweek,concentrationsofLp-PLA2wassignificantlyincreasedinotherthreegroupscomparedwiththecontrolgroup(P0.05);amongwhich,At12thweek,thelevelsofLp-PLA2increasedmoresignificantlyinthechronichypoxiagroupcomparedwiththehigh-fatgroup(P0.05);At12thweek,chronichypoxiahighadiposedietgroupincreasedmostsignificantlycomparedwiththeotherthreegroups(P0.05).3ByrepeatedmeasurementanalysisoxLDLandLp-PLA2levelsinplasma:whattherepeatedmeasurementtimeandthetreatmentgroupsinfluencesignificantlyonplasmalevelsofoxLDLandLp-PLA2wereobservde.Therehaveinteractioneffectbetweenrepeatedmeasurementtimeandthetreatmentgroups(P0.05).theplasmaexpressionofoxLDLandLp-PLA2werevariedwithdifferenttimeandgroups.ComparisonofWeight:Fromthe0thweektothe12thweek,wefoundthattheweightofthecontrolgroup,highfatgroup,chronichypoxiaandchronichypoxiahighadiposedietgroupincreasedtovaryingdegrees(P0.05).Butthereisnostatisticsignificanceinthegroupwithincomparisonofrabbit′sweightdifference(P0.05).Correlationanalysis:Throughcorrelationanalysis,wefoundthatthelevelsofoxLDLandLp-PLA2werenegativelycorrelatedwithweight(P0.05).Observationinpathologyintimatesthat，exceptthecontrolgroup，theaortasandabdominalaortaoftheothergroupshadvaryingdegreesoflocalatherosclerosispathologicalchanges.Conclusions1Chronichypoxiaandhigh-fatdietcanpromotetheNewZealandwhiterabbitsaorticarchandaortaatherosclerosisformation.Chronichypoxiaandhigh-fatdietcanpromotetheplasmaexpressionofoxLDLandLp-PLA2,therearevariedwithdifferenttime.TherearesignificantincreaseofoxLDLandLp-PLA2levelsandpromoteatherosclerosisformationinCooperationwithchronichypoxiaandhigh-fatdiet.KeyWords:hypoxia;atherosclerosis;Oxidizedlowdensitylipoprotein;lipoprotein-associatedPhospholipaseA2Directedby:Prof.LIUGuoRongApplicantforMasterdegree:YANJie（DepartmentofNeurology)(BaotouCentralHo