慢性乙型肝炎常见证型ldqol1.0量表与sf-36量表生命质量评价的比较分析-comparative analysis of life quality evaluation between ld qol 1.0 scale and sf - 36 scale for chronic hepatitis b.docxVIP

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2018-07-27 发布于上海
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慢性乙型肝炎常见证型ldqol1.0量表与sf-36量表生命质量评价的比较分析-comparative analysis of life quality evaluation between ld qol 1.0 scale and sf - 36 scale for chronic hepatitis b.docx

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慢性乙型肝炎常见证型ldqol1.0量表与sf-36量表生命质量评价的比较分析-comparative analysis of life quality evaluation between ld qol 1.0 scale and sf - 36 scale for chronic hepatitis b

PAGE PAGE 10 Abstract Objectives The objective of our study was to develop a reliable and valid liver disease quality of life instrument(LDQOL1.0) in Chinese Portuguese with chronic hepatitis B(CHB);re-evaluate different aspects of health related quality of life common syndrome of CHB with a relatively new questionnaire the LDQOL1.0;compare the differences between the LDQOL1.0 and the Short Form 36(SF-36) in the CHB with common syndromes. Methods The LDQOL1.0 consists of the SF-36 generic measure of HRQOL and 12 disease-specific dimensions for patients with CHB.Reliability was analyzed by studying the internal consistency of the individual disease-specific dimensions of the LDQOL1.0,as well as by study the split-half coefficient in a group of 753 patients who completed the questionnaire.Validity was analyzed by determining the instrument’s ability to discriminate groups of patients according to different syndromes of CHB.The LDQOL1.0 and the SF-36 questionnaire were applied to different syndromes of CHB,assess the quality of life between different syndromes,compare the differences between the LDQOL1.0 and the SF-36 questionnaire. All data were analyzed using the One-Way ANOVA and Chi-square test,T test,Multi-factor line regression method. Results Internal consistency reliability coefficient were excellent,ranging from 0.448 to 0.990,all scales 0.908,split-half coefficient provided strong support for item discrimination across the scales,and exploratory factor analysis demonstrated distinguishable physical,metal health dimensions. Significant associations were found between different syndromes.HRQOL of spleen deficiency was higher than other syndromes,HRQOL of syndromes with ―heat‖ were worse than other syndromes. LDQOL1.0 mostly focused on the mental problem while the SF-36 is mostly focused on the physical problem. Conclusions The LDQOL1.0,a specific instrument for measuring HRQOL,has shown a greater accuracy in relation to TCM syndromes and could demonstrate,w