妊娠期高盐饮食重编程血管紧张素系统介导成年子代心肌凋亡-reprogramming of high salt diet during pregnancy angiotensin system mediates myocardial apoptosis in adult offspring.docxVIP

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妊娠期高盐饮食重编程血管紧张素系统介导成年子代心肌凋亡-reprogramming of high salt diet during pregnancy angiotensin system mediates myocardial apoptosis in adult offspring.docx

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妊娠期高盐饮食重编程血管紧张素系统介导成年子代心肌凋亡-reprogramming of high salt diet during pregnancy angiotensin system mediates myocardial apoptosis in adult offspring

PAGE PAGE IV 妊娠期高盐饮食重编程血管紧张素系统介导成年子代心肌凋亡英文摘要 Maternal high salt intake during pregnancy reprogrammed renin-angiotensin system mediated cardiomyocyte apoptosis in the adult offspring heart Abstract PART1 The effects of maternal high-salt diet during pregnancy on the development of the heart and RAS in the offspring [Objective] To determine the changes in the heart and RAS in the offspring affected by maternal high-salt diet during pregnancy. [Methods] Sprague-Dawley rats were fed with high-salt food (HS) (8% NaCl) from gestation day 4 to 21. Control rats were fed with normal food(NS) (1% NaCl)during gestation. All rats were fed with normal food(1% NaCl) in the rest time of pregnancy. Offsprings were fed with standard food after weaning(4 weeks after born). Heart weight, body weight and blood values were measured in the newborn(2 days after birth), teenager (1month) and adult(5 months).Expression and distribution of AT1 and AT2 receptors in the heart of the newborn, adolescent and adult groups of NS and HS were evaluated using histological immunochemical staining and western blotting. [Results] The ratio of heart weight/body weight was higher in the HS adult offspring. The levels of AngⅡand ACE were significantly lower in the newborns in HS group. The structures of mitochondrial crest were changed. The expression of AT1 was significantly higher in all HS group, AT2 was higher in the HS adult offspring, while no differences were shown in the newborn and adolescent group. [Conclusion] Maternal high-salt diet during pregnancy may “reprogramming” the development of offspring heart and have impact on the RAS and distribution of AT1 and AT2 in the heart of offspring. Key words：maternal; high-salt; offspring; RAS; heart. 英文摘要妊娠期高盐饮食重编程血管紧张素系统介导成年子代心肌凋亡 PART2 The pro-apoptosis effects of maternal high-salt diet during pregnancy on myocardium and the intracellular signaling pathways [Objective] To investigate the relationship between RAS and apoptosis, in vivo and in vitr