甲状腺功能亢进并发甲亢性心脏病的危险因素分析.docVIP

甲状腺功能亢进并发甲亢性心脏病的危险因素分析 　　[摘 要] 目的：分析甲状腺功能亢进并发甲亢性心?K病的危险因素，总结防治对策。方法：80例甲亢性心脏病患者作为A组，65例单纯甲状腺功能亢进患者作为B组。比较两组患者年龄、性别、病程、个人史、实验室检查结果等临床资料，运用Logistic多因素回归分析，总结影响甲状腺功能亢进并发甲亢性心脏病的危险因素，探讨高危患者判别依据及干预策略。结果：年龄≥60岁、病程≥6个月、FT4≥35 pmol/L是影响甲亢并发甲亢性心脏病的独立危险因素（P0.05）。结论：应重视高龄、病程较长及高水平血清FT4者甲亢病情的控制。 　　[关键词] 甲状腺功能亢进；甲亢性心脏病；危险因素 　　中图分类号：R581 文献标识码：A 文章编号：2095-5200（2017）05-043-03 　　DOI：10.11876/mimt201705018 　　Analysis of risk factors of hyperthyroid heart disease complicated with hyperthyroidism WANG Wenjun， CHENG Qiushi. （Department of Endocrinology，Qingdao Municipal Hospital， Qingdao 266000， china） 　　[Abstract] Objective： The objective of this study was to analyze the risk factors of hyperthyroid heart disease complicated with hyperthyroidism and to summarize countermeasures of prevention and cure. Methods： A total sample of 145 patients were selected as objects of study including 80 patients with hyperthyroid heart disease as A group and 65 patients with simple hyperthyroidism as group B. The clinical data were compared between the two groups in age， gender， disease duration， personal history and laboratory examination results， and Logistic multivariate regression analysis was used， in order to summarize the risk factors of hyperthyroid heart disease complicated with hyperthyroidism and to explore the distinguish basis and intervention strategy of high-risk patients. Results： Age≥60， disease duration≥6 months and FT4≥35 pmol/L were independent risk factors of hyperthyroid heart disease complicated with hyperthyroidism （P0.05）. Conclusions： Attention should be paid to the control of hyperthyroidism patients with advanced age， longer course and high levels of serum FT4. 　　[Key words] hyperthyroidism； hyperthyroid heart disease； risk factors 　　甲亢患者常伴有心率加快、心肌收缩力增强、全血容量容量增加、外周血管阻力降低等病理生理改变[1]，心血管系统处于高动力状态，加之过量甲状腺激素对心脏的直接毒性作用，均导致甲亢患者心脏疾病发生风险较高[2]。甲亢性心脏病约占甲亢患者的10%～20%，患者往往病程较长、年龄较大[3]。因此，在注重甲亢性心脏病早期诊断的前提下，进一步明确甲亢性心脏病的危险因素、预防甲亢向甲亢性心脏病进展，对于改善患者预后及生存质量均具有重要意义。为此，本研究选取145例患者进行了对照分析，现