脊柱结核ppt课件_16.pptVIP

1、Monocyte Chemotactic Protein-1 -2518 Gene Polymorphism and Susceptibility to Spinal Tuberculosis单核细胞趋化蛋白-1-2518的基因多态性与脊柱结核的敏感性。2、Enzyme-linked immunospot assay response to recombinant CFP-10/ESAT-6 fusion protein among patients with spinal tuberculosis: implications for diagnosis and monitoring of surgical therapy酶联免疫斑点技术对脊柱结核患者中重组CFP-10/ESAT-6 融合蛋白的反应性：诊断与外科手术治疗监测的意义。;1、Monocyte Chemotactic Protein-1 -2518 Gene Polymorphism and Susceptibility to Spinal Tuberculosis 单核细胞趋化蛋白-1-2518的基因多态性与脊柱结核的敏感性。 （Department of Spine Surgery, Xiangya Hospital, Central South University, Hunan, China Clinical Laboratory, Secondary Affiliated Hospital, Fujian Medical University, Fujian, China） Archives of Medical Research 45 (2014);Background and Aims. Monocyte chemotactic protein-1 (MCP-1) gene polymorphisms play important roles in regulating immunological reactions and may be associated with pulmonary tuberculosis. However, the relationship between the MCP-1 -2518 gene polymorphism and susceptibility to spinal tuberculosis remains unknown. 背景与目的 单核细胞趋化蛋白-1（MCP-1）基因多态性在调节免疫反应中发挥重要作用，可能与肺结核的发生密切相关。然而，在MCP-1-2518基因多态性与其对脊柱结核敏感性之间的关系尚不清楚。; We undertook this study to investigate the relationships between MCP-1 promoter 2518 genotype frequency and allele polymorphisms and susceptibility to spinal tuberculosis in a Chinese Han population. 本研究旨在探讨中国汉族人群中MCP-1基因启动子2518基因型频率和等位基因多态性与脊柱结核易感性的关系。 ;Methods. Patients with spinal tuberculosis and healthy volunteers were enrolled between December 2004 and December 2010. MCP-1 -2518 polymorphisms in both groups were detected using polymerase chain reaction and DNA sequencing. MCP-1 genotype was analyzed in all patients. Differences in genotype frequencies between groups were compared using χ2tests. 方法： 选取2004年12月至2010年12之间的脊柱结核病人和 健康志愿者纳入到本研究中。两组均采用聚合酶链反应和DNA序列测定来检测MCP-1 -2518 基因多态性，所有患者的MCP-1基因型均进行了分析。采用χ2检验来比较组间基因型频率差异。;Results. A total of 208 patients with spinal tuberculosis and 210