Ang―2和VEGF在肾细胞癌患者外周血中表达及其意义.docVIP

Ang―2和VEGF在肾细胞癌患者外周血中表达及其意义 　　【摘要】 目的：检测促血管生成素-2（Angiopoietin-2，Ang-2）和血管内皮生长因子（vascular endothelial growth factor，VEGF）在肾细胞癌患者外周血中的表达，探讨两者的变化及其相互关系。方法：收集56例肾细胞癌患者按肿瘤分期分为实验1、2、3组，30例健康人为对照组，采用ELISA方法分别检测标本Ang-2、VEGF的水平，对以上数据进行比较。结果：四组的VEGF两两比较，差异均有统计学意义（P0.05）；实验3组的Ang-2高于实验1组、实验2组、对照组，对照组的Ang-2低于实验1、2、3组，差异均有统计学意义（P0.05）。肾细胞癌患者血清VEGF和Ang-2呈正相关（r=0.732，P0.05）。结论：Ang-2、VEGF在肾细胞癌患者外周血中呈高表达，且与临床分期关系密切，Ang-2和VEGF在肾细胞癌血管生成中可能相互影响。 　　【关键词】 肾细胞癌； 促血管生成素-2； 血管内皮生长因子 　　The Expression and Significance of Ang-2 and VEGF in Peripheral Blood of Renal Cell Carcinoma Patient/HAN Hui，WANG Yong-gang，LIU Shang-ying.//Medical Innovation of China，2017，14（27）：110-112 　　【Abstract】 Objective：To investigate the expression of angiopoietin-2 and vascular endothelial growth factor in peripheral blood of patients with renal cell carcinoma，and to explore the changes and their relationship.Method：56 renal cell carcinoma patients were selected，according to the tumor stage were divided into experimental group 1，2，3，30 healthy people were selected as the control group，specimens was detected by ELISA method Ang-2，the levels of VEGF，the above data were compared.Result：The differences between the four groups of VEGF compsred were statistically significant（P0.05）；the Ang-2 of experimental group 3 was higher than the experimental group 1，experimental group 2，control group，the Ang-2 of the control group was lower than the experimental group 1，2，3，the differences have the statistical significance（P0.05）.Serum VEGF and Ang-2 were positively correlated in patients with renal cell carcinoma（r=0.732，P0.05）.Conclusion：Ang-2 and VEGF are highly expressed in peripheral blood of patients with renal cell carcinoma and are closely related to clinical stages， and Ang-2 and VEGF may interact with each other in the angiogenesis of renal cell carcinoma. 　　【Key words】 Renal cell carcinoma； Angiopoietin-2； Vascular endothelial growth factor 　　First-author’s address：Shanxi Medical University，Taiyuan 030001，China