MMP9VEGF在人喉鳞癌组织中表达及临床意义.docVIP

MMP9VEGF在人喉鳞癌组织中表达及临床意义.doc

  1. 1、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。。
  2. 2、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载
  3. 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
  4. 4、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
  5. 5、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们
  6. 6、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
  7. 7、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
MMP9VEGF在人喉鳞癌组织中表达及临床意义

MMP9VEGF在人喉鳞癌组织中表达及临床意义   [摘要] 目的:探讨MMP-9、VEGF在喉鳞癌组织中的表达及临床病理学意义。方法:①免疫组化法检测75例喉癌患者MMP-9及VEGF的表达情况;②利用Spearman秩相关检验分析MMP-9及VEGF的表达与喉癌相关临床参数的关系。结果:①MMP-9表达在声门上型喉癌中与颈淋巴结转移存在正相关(r=0.553,P=0.011),而在声门型喉癌中却无相关性(r=0.219,P=0.382);VEGF表达在声门上型喉癌中与颈淋巴结转移存在正相关(r=0.362,P=0.018),而在声门型喉癌中却无相关性(r=0.189,P=0.453);②MMP-9表达与VEGF表达之间存在正相关(r=0.775,P=0.000),且MMP-9表达、VEGF表达均与临床分期、颈淋巴结转移呈正相关(r=0.468,P=0.003;r=0.402,P=0.012),与年龄等因素无关。结论:MMP-9、VEGF的表达与喉鳞癌的侵袭、颈淋巴结转移有关,两者可能在喉鳞癌的发生、发展中起重要作用。   [关键词] 喉鳞癌;MMP-9;VEGF;免疫组化   [中图分类号] R739.6[文献标识码]A [文章编号]1673-7210(2010)10(b)-012-03      Expression and clinical significance of MMP-9 and VEGF in human laryngeal squamous cell carcinoma   DONG Huilei1, GUO Xing2*, LI Zhendong1   (1.Department of Head and Neck Surgery, Liaoning Cancer Hospital Institute, Shenyang 110042, China; 2.Department of Otolaryngology Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, China)   [Abstract] Objective: To investigate the expression and clinical significance of MMP-9 and VEGF in human laryngeal squamous cell carcinoma. Methods: MMP-9 and VEGF expression in surgically resected tissue samples of laryngeal carcinomas (n=75) were examined immunohistochemically, and their correlations with clinicopathological factors were analyzed. Results: ①Significant positive correlation was revealed between MMP-9 expression and lymph node metastasis in supraglottic carcinoma (r=0.553, P=0.011), and no correlation in glottic carcinoma (r=0.219, P=0.382); and significant positive correlation was revealed between VEGF expression and lymph node metastasis in supraglottic carcinoma (r=0.362, P=0.018), and no correlation in glottic carcinoma (r=0.189, P=0.453). ②The expression of MMP-9 was positively correlated with VEGF (r=0.775, P=0.000), the expressions of MMP-9 and VEGF were positively correlated with clinical staging of laryngeal carcinoma and the neck lymph node metastasis (r=0.468, P=0.003; r=0.402, P=0.012). In contrast, the level of MMP-9 a

文档评论(0)

3471161553 + 关注
实名认证
文档贡献者

该用户很懒,什么也没介绍

1亿VIP精品文档

相关文档