SLC26蛋白家族成员功能及意义研究进展.docVIP

SLC26蛋白家族成员功能及意义研究进展 　　[摘要] 目前研究发现人类许多疾病与离子通道蛋白相关，故对于离子通道蛋白如何参与人类疾病的发展已成为各大学者的研究热点。SLC26阴离子通道蛋白家族作为目前一类研究较多的离子通道蛋白，具有成员多、结构功能复杂多样等特点，可作为SO42-转运蛋白、阴离子交换器、阴离子通道蛋白等在组织上的特异性表达来发挥其功能，SLC26阴离子通道蛋白家族的表达及功能受多种机制调节，其家庭成员结构及功能变化与人类先天性营养不良、先天性氯化物腹泻、先天性耳聋及消化道疾病等多种人类疾病相关。本文就SLC26蛋白家族其结构功能、各家族成员及其主要功能、相关调节因素及其与相关疾病的关系等进行综述。 　　[关键词] SLC26蛋白家族；SLC26蛋白结构功能；相关调节因素 　　[中图分类号] R969 [文献标识码] A [文章编号] 1674-4721（2015）05（b）-0027-05 　　Research progress on the function and significance of SLC26 protein family 　　RAN Li-dan1 CAI Xiao-li1 LIU Xue-mei2 WEN Guo-rong2 JIN Hai2 TUO Bi-guang2▲ 　　1.Zunyi Medical College，Guizhou Province，Zunyi 563000，China；2.Department of Gastroenterology，Affiliated Hospital of Zunyi Medical College，Guizhou Province，Zunyi 563000，China 　　[Abstract] At present，the study found that many human diseases associated with a number of ion channel proteins，so the study of how an ion channel proteins involved in the development of human diseases channel has become a hot topic of major scholars.SLC26 anion channel protein family as a kind of research is currently more ion channel proteins，with the characteristics of more members and complicated structure and function，which can be used as SO42- transporters，anion exchanger，anion channel protein is specifically expressed in the tissue to exert its function，its expression and function by a variety of mechanisms regulating their family members，the structure and function of changes are associated with a variety of human diseases for human congenital malnutrition，congenital chloride diarrhea，congenital deafness，digestive tract diseases，etc.This article makes a discussion on the SLC26 protein family in its structure and function， family members，and the main functions of related regulation and related disease relationship. 　　[Key words] SLC26 protein family；SLC26 protein structure and function；Related regulating factors 　　近年来诸多研究发现离子通道蛋白可通过调节细胞膜电位、改变细胞形态、细胞内外离子浓度差及pH值的变化、改变表达部位及功能活性等参与调节肿瘤的血管形成、增殖、转移及凋亡等，为探究肿瘤发生机制、预防及治疗提供了新的思路[1-