Lp―PLA2hs―CRP水平在急性脑梗死患者中变化及对病情预测作用.docVIP

Lp―PLA2hs―CRP水平在急性脑梗死患者中变化及对病情预测作用 　　【摘要】 目的：探讨血清脂蛋白相关磷脂酶A2（lipoprotein associated phospholipase A2，Lp-PLA2）和超敏C反应蛋白（high-sensitivity C reactive protein，hs-CRP）水平在急性脑梗死患者中的变化及对病情的预测作用。方法：选取2014年1月-2015年1月本院神经内科收治的急性脑梗死患者124例作为研究组，根据脑梗死体积将其分为A组52例、B组38例、C组34例，根据神经功能缺损程度将其分为轻度梗死组48例、中度梗死组38例、重度梗死组38例，另择同期120例健康体检者作为对照组。采用ELISA检测血清Lp-PLA2水平，免疫比浊法检测血清hs-CRP，比较不同病情程度患者血清指标的差异。结果：研究组血清Lp-PLA2和hs-CRP水平均明显高于对照组，比较差异均有统计学意义（P0.05）；A组Lp-PLA2和hs-CRP明显低于B、C组，B组低于C组，比较差异有统计学意义（P0.05）；轻度梗死组Lp-PLA2和hs-CRP低于中重度梗死组，中度梗死组低于重度梗死组，比较差异有统计学意义（P0.05）。经Pearson相关性分析显示，血清Lp-PLA2、hs-CRP水平与急性脑梗死病情严重程度均呈明显相关性（P0.05）。结论：Lp-PLA2和hs-CRP水平在急性脑梗死患者中显著增高，对病情程度具有重要的预测作用。 　　【关键词】 脂蛋白相关磷脂酶A2； 超敏C反应蛋白； 急性脑梗死 　　【Abstract】 Objective：To investigate serum lipoprotein associated phospholipase A2 （LP-PLA2） and high sensitive C reactive protein （hs-CRP） levels changes and severity predictive role in patients with acute cerebral infarction.Method：From January 2014 to January 2015，124 cases of acute cerebral infarction treated in our hospital neurology were selected as the study group，they were divided into 52 cases in group A，38 cases in group B and 34 cases in group C according to the volume of cerebral infarction；they were divided into 48 cases of mild infarction group，38 cases of moderate infarction group and 38 cases of severe infarction group according to the degree of neurological impairment，another 120 cases of healthy physical examination were selected as the control group.The serum Lp-PLA2 level was detected by ELISA and serum level of hs-CRP was detected by immunoturbidimetry，the differences of serum indexes of patients with different degree of disease were compared.Result：Serum Lp-PLA2 and hs-CRP levels of study group were significantly higher than control group，the differences were statistically significant（P 　　【Key words】 Lipoprotein associated phospholipase A2； High sensitive C reactive protein； Acute cerebral infarction 　　First-author’s address：The Second People’s Hospital of Foshan City，Fo