CEACA72―4在结直肠癌中应用价值探讨.docVIP

CEACA72―4在结直肠癌中应用价值探讨 　　【摘 要】目的 对结直肠癌患者采用血清肿瘤标志物癌胚抗原（CEA）、糖类抗原CA72-4进行检测，探讨两种抗原对患者的诊断预后价值，为结直肠癌的临床诊断提供参考依据。方法 选取80例经病理证实的结直肠癌患者作为观察组，另选取同期进行体检的健康人群30例作为对照组，并对28例术后患者的血清进行检测。结果 结直肠癌患者DukesB、C、D期的CEA和CA72-4与对照组患者比较均显著升高（P0.05）。血清CEA和CA72-4水平随着临床分期的严重程度而逐渐升高。其中在28例患者中，其术前的血清CEA为26.9±23.2ng/mL，CA72-4为8.9±5.9u/mL；术后血清CEA为2.7±1.3ng/mL，CA72-4为4.2±2.8u/mL，术后的血清水平均显著低于术前（P0.05）。结论 在结直肠癌患者中通过联合检测血清肿瘤标志物CEA和CA72-4可明显提高结直肠癌患者的诊断敏感性及有效性，对疾病的诊断、术后监测和预后情况的判定等均具有较高的价值，值得推广应用。但诊断的特异性有所降低，值得进一步的深入探究。 　　【关键词】结直肠癌；肿瘤标记物；癌胚抗原CEA；糖类抗原CA72-4 　　The application of CEA and CA72-4 in colorectal cancer 　　Xu Bing-xin1，2，Xue Jiang-nan1 　　1 Binzhou Medical University，Shandong Yantai 251632；2 Department of laboratory，Wudi Peoples Hospital，Shandong Province，Shandong Wudi 251900 　　ABSTRACT：Objective To investigate the diagnostic value of serum tumor markers（CEA）and carbohydrate antigen（CA72-4）in patients with colorectal cancer，and to provide a reference for the clinical diagnosis of colorectal cancer.Methods 80 patients with colorectal cancer who were confirmed by pathology were selected as the observation group，and 30 healthy people as control group were selected as the control group.Results DukesB，C，CEA and D in patients with colorectal cancer were significantly higher（CA72-4）compared with the control group（P0.05）.The levels of serum CEA and CA72-4 gradually increased with the severity of clinical stage.Among the 28 patients，the serum CEA was 26.9±23.2ng / mL，CA72-4 was 8.9±5.9u/ mL，CEA was 2.7 ± 1.3ng / mL，CA72-4 was 4.2 ± 2.8u / mL，the serum level of the patients was significantly lower than that before operation（P0.05）.Conclusion CEA and CA72-4 can significantly improve the diagnostic sensitivity and validity of the patients with colorectal cancer，and it has a high value in the diagnosis of diseases，postoperative monitoring and prognosis，and is worthy of popularization and application.However，the specificity of diagnosis has been reduced，it is worth further exploration. 　　KEY WORDS：Colo