SP―A测定与新生儿呼吸窘迫综合征相关性研究.docVIP

SP―A测定与新生儿呼吸窘迫综合征相关性研究 　　[摘要] 目的 探讨SP-A含量与新生儿呼吸窘迫综合征的关系。 方法 对我院出生的胎龄小于34周的早产儿， 统一测定SP-A，按胎龄分组，计算各组SP-A含量，计算每组NRDS发生率；将发生呼吸窘迫综合征的患儿作为观察组，未发生的作为对照组，比较SP-A含量差异；计算早产儿呼吸窘迫综合征SP-A含量95%医学参考值。结果 98例早产儿有32例发生了NRDS，两组SP-A含量比较差异有统计学意义，推断早产儿发生NRDS SP-A含量医学参考值为11.68 ng/mL。 结论 SP-A含量增加，NRDS发生率降低；胎龄增大，SP-A含量增大；发生与未发生NRDS的患儿的SP-A含量差异有统计学意义，推断早产儿发生RDS医学参考值为11.68 ng/mL，为以后临床工作中快速测定该值，预测发生NRDS，并进行早期应用PS制剂提供理论依据。 　　[关键词] 表面活性蛋白A；新生儿呼吸窘迫综合征；医学参考值 　　[中图分类号] R722.1 [文献标识码] B [文章编号] 1673-9701（2015）09-0035-03 　　The study of association between levels of SP-A and neonatal respiratory distress syndrome 　　ZHANG Kegang LI Yan ZHOU Guangju 　　Department of Pediatrics， Maternal and Child Health Hospital of Zaozhuang City in Shandong Province， Zaozhuang 277100，China 　　[Abstract] Objective To study the relationship between levels of SP-A and the occurrence of premature infants with respiratory distress syndrome （RDS）. Methods The premature infants of gestational age 34 weeks were collected in our hospital. The premature infants with RDS as the observation group， non as the control group， and the levels of SP-A were analyzed and compared between the two groups.And then the 95% medical reference range of levels of SP-A of premature infants with RDS was calculated by statistical methods. Results There was significant difference between the two groups（P0.01）， the 95% medical reference range of levels of SP-A of premature infants with RDS was 11.68 ng/mL. Conclusion The level of SP-A was significantly correlated between the occurrence of premature infants with RDS. The 95% medical reference range of levels of SP-A of premature infants provide the theory for the early application of pulmonary surfactant. 　　[Key words] Pulmonary surfactant associated protein A（SP-A）； Neonatal respiratory distress syndrome（NRDS）； Medical reference range 　　新生儿呼吸窘迫综合征（neonatal respiratory distress syndrome，NRDS），是指出生后不久出现进行性呼吸困难、青紫、呼气性呻吟、吸气性三凹征和呼吸衰竭，为肺表面活性物质（pulmonary surfactant，PS）缺乏所致[1]，多见于早产儿，PS主要由肺泡Ⅱ型细胞合成、分泌，覆