二甲双胍治疗糖尿病前期疗效观察.docVIP

二甲双胍治疗糖尿病前期的疗效观察 　　【摘要】 目的：研究二甲双胍在糖尿病前期中的应用价值。方法：选取2011年12月-2013年12月笔者所在医院收治的68例糖尿病前期患者，按照随机数字表法将其分为两组，每组34例。对照组采用常规运动干预、饮食控制治疗，观察组在对照组基础上给予二甲双胍片治疗，比较两组患者的治疗效果，并了解观察组患者是否发生不良反应。结果：观察组显效23例，有效10例，总有效率为97.1%；对照组显效18例，有效6例，总有效率为76.5%，观察组总有效率优于对照组，差异有统计学意义（P0.05）。观察组中2例患者发生糖尿病，发生率为5.9%，对照组中8例患者发生糖尿病，发生率为23.5%，观察组糖尿病发生率低于对照组，差异有统计学意义（P0.05）。结论：通过采用二甲双胍对糖尿病前期患者进行治疗，可以有效改善患者血糖水平，值得临床推广应用。 　　【关键词】 二甲双胍片； 糖尿病前期； 临床疗效 　　中图分类号 R587.1 文献标识码 B 文章编号 1674-6805（2015）19-0023-03 　　【Abstract】 Objective：To study the applied value of Metformin in the treatment of pre-diabetes.Method：68 cases of patients with pre-diabetes in our hospital from December 2011 to December 2013 were selected，they were randomly divided into two groups，34 cases in each group.The control group was given routine exercise intervention，diet therapy，the observation group on the basis of the control group was given metformin treatment，the effect of two groups were compared，and the adverse reaction of the observation group was observed.Result：In the observation group，23 cases had marked effect，10 cases were effect，the total effective rate was 97.1%.The control group，18 cases had marked effect，8 cases were effect，the total effective rate was 76.5%，the total effective rate of the observation group was higher than that of the control group，there was statistical significance（P0.05）.The incidence rate of the observation group was 2.9%，no adverse reactions in patients of the control group，there was no statistical significance（P0.05）.There were 2 cases of patients with diabetes in the observation group，the incidence rate of the observation group was 5.9%，the control group was 20.6%，there was statistical significance（P0.05）.Conclusion：By adopting of pre-diabetes patients were treated with Metformin，can effectively improve the patients blood glucose levels，it is worthy of clinical application. 　　【Key words】 Metformin Tablets； Pre-diabetes； Clinical effect 　　糖尿病的主要临床表现为血糖升高，它属于慢性代谢疾病，伴随病程不断发展，会出现全身代谢紊乱现象，损害患者重要器官，对患者生命构成