二甲双胍结合胰岛素在妊娠期糖尿病孕妇新生儿神经发育中研究应用.docVIP

二甲双胍结合胰岛素在妊娠期糖尿病孕妇、新生儿神经发育中的研究应用 　　[摘要] 目的 探究二甲双胍结合胰岛素在妊娠期糖尿病孕妇、新生儿神经发育中的研究应用。 方法 该研究选择2014年5月1日―2015年11月1日在该院住院治疗的妊娠期糖尿病患者90例，随机分成联合组和对照组，分别使用甲双胍结合胰岛素和胰岛素治疗，观察两组患者分娩新生儿的神经系统发育及其血糖的控制情况比较。结果 联合组患者分娩的新生儿在主动肌张力和NBNA总分上，都要高于对照组患者分娩的新生儿，两组新生儿神经系统评价结果差异有统计学意义（t=4.698，P=0.0210.05）、（t=4.429，P=0.0140.05）；联合组共有40例患者控制在血糖正常水平，对照组共有24例患者控制在血糖正常水平，两组结果差异有统计学意义（χ2=13.684，P=0.0000.05）；联合组患者分娩的新生儿神经系统正常的有43例，对照组有32例，两组结果差异有统计学意义（χ2=9.680，P=0.0030.05）。 结论 针对妊娠期糖尿病患者应用二甲双胍结合胰岛素治疗，能够高效的控制患者的血糖水平，改善新生儿的神经系统发育情况，保证了孕妇和新生儿的安全，值得在临床广泛应用。 　　[关键词] 二甲双胍；妊娠期糖尿病；神经发育 　　[中图分类号] R587.1 [文献标识码] A [文章编号] 1672-4062（2016）05（a）-0013-02 　　[Abstract] Objective Inquiry combined with metformin in insulin Application gestational diabetes in pregnant women， newborns neural development. Methods In this study， patients with gestational diabetes in our hospital 90 patients were randomly divided into combination group and control group， respectively， using insulin and insulin-metformin combination therapy， were observed in patients with neonatal birth nervous system and blood sugar control Compare the situation. Results Joint newborns patients on the active muscle tension and NBNA out， the patient should be higher in newborns， neonatal neurologic evaluation results are two significant differences （t=4.698， P=0.0210.05），（t=4.429，P=0.0140.05）； the joint control group consisted of 40 patients with normal blood glucose levels in the control group consisted of 24 patients in the control of blood glucose to normal levels， the results of the two groups were significantly different（χ2=13.684，P=0.0000.05）； the combined group of patients newborns normal nervous system， 43 patients in the control group， 32 cases， the difference between these two groups was significantly （χ2=9.680，P=0.0030.05）. Conclusion For gestational diabetes insulin therapy in combination with metformin， can efficiently control blood sugar levels in patients， improve the development of the situation of the nervous system of newborns to ensure t