亚临床甲状腺功能异常患者血脂血糖水平变化及相关影响因素分析.docVIP

亚临床甲状腺功能异常患者血脂、血糖水平的变化及相关影响因素分析 　　[摘要] 目的 探讨亚临床甲状腺功能异常患者血脂、血糖水平的变化及相关影响因素。 方法 选取2011年7月～2015年6月我院收治的300例促甲状腺激素（TSH）5.500 mU/L设为亚临床甲减组、304例健康体检者设为健康对照组，采用t检验比较亚临床甲亢组、亚临床甲减组与健康对照组的低密度脂蛋白胆固醇（LDL）、高密度脂蛋白胆固醇（HDL）、三酰甘油（TG）、总胆固醇（TC）和空腹血糖（GLU）水平，采用Pearson法分析患者的TSH、甲状腺素（T4）、三碘甲状腺原氨酸（T3）、游离甲状腺素（FT4）、游离三碘甲状原氨酸（FT3）水平与上述血脂、血糖水平的相关性，使用Logistic回归分析亚临床甲状腺功能异常患者上述血脂、血糖指标的影响因素。 结果 与健康对照组比较，亚临床甲亢组的HDL水平显著升高（t=2.119，P=0.034），亚临床甲减组的TC水平显著升高（t=2.036，P=0.042）；亚临床甲亢组的FT3水平与其HDL水平呈显著正相关（r=0.107，P=0.009），亚临床甲减组的T4水平与GLU水平呈显著负相关（r=-0.104，P=0.044），FT3与HDL、GLU分别呈显著正、负相关（r=0.105，P=0.042；r=-0.113，P=0.028）；吸烟史是患者TG水平异常的危险因素（P=0.023，OR=1.547，95%CI：0.740～1.806）。 结论 亚临床甲状腺功能异常患者的血脂水平异常，且与部分甲状腺功能指标相关，吸烟是患者血脂异常的危险因素。 　　[关键词] 亚临床甲状腺功能亢进；亚临床甲状腺功能减退；血脂；血糖 　　[中图分类号] R581 [文献标识码] A [文章编号] 1674-4721（2016）01（c）-0111-04 　　[Abstract] Objective To explore the change and affecting factors of blood lipid and glucose level in patients with subclinical thyroid dysfunction. Methods 300 subclinical thyroid dysfunctional patients with TSH5.500 mU/L were set as subclinical hypothyroidism group，and 300 healthy examined persons were set as healthy control group from July 2011 to June 2015，then t test was used to compare the LDL，HDL，TG，TC，and GLU level between subclinical hyperthyroidism group，subclinical hypothyroidism group and healthy control group，while Pearson analysis method was used to detect the relationship between these indictors with TSH，T4，T3，FT4，and FT3，and Logistics regression was used to analyze the affecting factors for blood lipid and glucose level. Results Compared with healthy control group，HDL level in subclinical hyperthyroidism group was significantly rised （t=2.119，P=0.034），and TC level in subclinical hypothyroidism group was significantly rised （t=2.036，P=0.042）.In subclinical hyperthyroidism group，FT3 level was positively correlated with HDL level （r=0.107，P=0.009），while in subclinical hypothyroidism group，T4 level was negatively correlated with GLU level （r=-0.104，P=0.044），FT3 level was pos