促血管生成素―2在肾细胞癌中表达及其意义.docVIP

促血管生成素―2在肾细胞癌中的表达及其意义 　　【摘要】 目的：研究促血管生成素-2（Angiopoietin-2，Ang-2）在肾细胞癌中的表达及其意义。方法：用免疫组化SP法检测50例肾细胞癌组织、配对癌旁组织以及6例正常肾组织中的Ang-2，并结合临床资料进行具体分析。结果：Ang-2在肾细胞癌组织、癌旁组织及正常肾组织中的阳性表达率分别为62.0%（31/50）、28.0%（14/50）和0（0/6），三者比较差异有统计学意义（P0.05）。Ang-2在Ⅰ～Ⅱ期和Ⅲ～Ⅳ期的阳性表达率分别为51.4%（19/37）和92.3%（12/13）；Ang-2在术前有血尿组和无血尿组的阳性表达率分别为85.7%（12/14）和52.8%（19/36），两者比较差异均有统计学意义（P0.05）。结论：Ang-2在肾细胞癌组织表达明显高于非癌组织，表明其在肾细胞癌的发生发展中起重要作用，与肾细胞癌的分期、转移有关。 　　【关键词】 肾细胞癌； 促血管生成素-2； 免疫组化 　　【Abstract】 Objective：To study the expression and significance of Ang-2 in renal cell carcinoma. Method：The expression of Ang-2 was measured by immunohistochemistry in tissue sections from 6 cases of normal renal tissues， 50 cases of RCC and their pericarcinous tissues，their correlation with clinical data features were analyzed.Result：The positive rate for expression of Ang-2 in RCC， their pericarcinous and normal renal tissue were respectively 62.0%（31/50），28.0%（14/50） and 0（0/6），the expression of Ang-2 in RCC was significantly higher than those in pericarcinous tissue and normal renal tissue，the difference was statistically significant among them（P0.05）.The positive expression rates of Ang-2 in the stages of Ⅰ-Ⅱ and Ⅲ-Ⅳ were respectively 51.4%（19/37） and 92.3%（12/13），the positive expression rates of Ang-2 in the stages of Ⅲ-Ⅳ was higher than those in the stages of Ⅰ-Ⅱ；the positive expression rates of Ang-2 in patients with and without hematuresis were respectively 85.7%（12/14） and 52.8%（19/36），the positive expression rates of Ang-2 in RCC with hematuresis was higher than those without hematuresis，the differences were statistically significant（P0.05）.Conclusion：The expression of Ang-2 in the RCC is higher than those in the noncancerous renal tissue，which indicates that it may play an important role during the development of RCC.It has relationship to RCC angiogenesis， clinical stage and metastasis. 　　【Key words】 Renal cell carcinoma； Angiopoietin-2； Immunohistochemical stain 　　First-author’s address：Shanxi Medical University，T