匹维溴铵联合酪酸梭菌活菌治疗肠易激综合征疗效观察.docVIP

匹维溴铵联合酪酸梭菌活菌治疗肠易激综合征疗效观察 　　【中图分类号】R574.4【文献标识码】A【文章编号】1005-2720(2010)06 - 07 - 02 　　【摘要】目的 探讨匹维溴胺联合酪酸梭菌活菌(米桑)治疗肠易激综合征(IBS)的临床疗效。方法 选择54例IBS患者,随机分为对照组和治疗组各27例。对照组口服匹维溴胺50 mg,3次/d;治疗组在此基础上加服酪酸梭菌活菌400mg,3次/d;疗程均为4周;观察两组治疗后腹痛、腹泻、便秘等症状变化及临床疗效。结果 治疗组总有效率为92.6%,对照组总有效率为66.7%,治疗组优于对照组,差异有统计学意义(P0.05)。结论 匹维溴胺联合酪酸梭菌活菌可有效改善IBS患者的临床症状,提高疗效。 　　【关键词】肠易激综合征;匹维溴胺;酪酸梭菌活菌 　　To observe the therapeutic effects of pinaverium bromide combined with clostridium butyricum in the treatment of irritable bowel syndrome 　　ZHANG Lianggen 　　 (Guangcheng Community Health Service Centre of Pinghu City,Zhejiang,314207,China) 　　【Abstract】Objective To study the therapeutic effects of pinaverium bromide combined with clostridium butyricum in the treatment of irritable bowel syndrome (IBS).Methods 54 patients with IBS were randomly divided into two groups:the control group (n = 27) and the treatment group (n = 27).The patients in the control group were treated with pinaveriunm bromide 50mg three times daily,and those in the treatment group were given clostridium butyricum 400mg three times daily based on the above treatment.The period of treated was 4 weeks.The clinical efficacy,change of abdominal pain,diarrhea,constipation and other symptoms were observed after the treatment.Results The total effective rate was 66.7% in the control group and 92.6% in the treatment group,there was significant difference between the two groups (P 0.05).The clinical efficacy of the treatment group was significantly better than that of the control group.Conclusion The pinaverium bromide combined with clostridium butyricum can effectively improve the clinical symptoms of patients with IBS and increase the therapeutic effects. 　　【Key words】Irritable bowel syndrome (IBS);Navedum bromide;Clostridium butyricum 　　 　　肠易激综合征(IBS)是一种与肠道动力和内脏感觉异常有关的功能性胃肠病,是一组包括排便习惯改变、粪便性状异常和腹痛、腹胀等临床表现的症候群。该病发病机制较为复杂,相关的治疗方法颇多。笔者应用匹维溴胺联合酪酸梭菌活菌(米桑)治疗IBS,取得了较好疗效,现将结果报道如下。 　　1 资料与方法 　　1.1 病例选择所有病例均为2006年7月至2009年6月在我中心内科就诊的门诊病人,均符合罗马Ⅲ诊断标准[1